Randle JCR - Search Results

1

Chimeras Derived from a P2Y₁₄ Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation.

Wen Z, Pramanik A, Lewicki SA, Jung YH, Gao ZG, Randle JCR, Breton S, Chen Z, Whitehead GS, Salvemini D, Cook DN, Jacobson KA. Wen Z, et al. Among authors: randle jcr. ACS Pharmacol Transl Sci. 2024 Sep 26;7(10):3255-3278. doi: 10.1021/acsptsci.4c00489. eCollection 2024 Oct 11. ACS Pharmacol Transl Sci. 2024. PMID: 39421658

2

Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y₁₄ Receptor Antagonists.

Wen Z, Pramanik A, Lewicki SA, Jung YH, Gao ZG, Randle JCR, Cronin C, Chen Z, Giancotti LA, Whitehead GS, Liang BT, Breton S, Salvemini D, Cook DN, Jacobson KA. Wen Z, et al. Among authors: randle jcr. J Med Chem. 2023 Jul 13;66(13):9076-9094. doi: 10.1021/acs.jmedchem.3c00664. Epub 2023 Jun 29. J Med Chem. 2023. PMID: 37382926 Free PMC article.

3

Structure-Activity Relationship of Heterocyclic P2Y₁₄ Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres.

Jung YH, Salmaso V, Wen Z, Bennett JM, Phung NB, Lieberman DI, Gopinatth V, Randle JCR, Chen Z, Salvemini D, Karcz TP, Cook DN, Jacobson KA. Jung YH, et al. Among authors: randle jcr. J Med Chem. 2021 Apr 22;64(8):5099-5122. doi: 10.1021/acs.jmedchem.1c00164. Epub 2021 Mar 31. J Med Chem. 2021. PMID: 33787273 Free PMC article.

4

Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y₁₄R Antagonist.

Wen Z, Salmaso V, Jung YH, Phung NB, Gopinatth V, Shah Q, Patterson AT, Randle JCR, Chen Z, Salvemini D, Lieberman DI, Whitehead GS, Karcz TP, Cook DN, Jacobson KA. Wen Z, et al. Among authors: randle jcr. J Med Chem. 2022 Feb 24;65(4):3434-3459. doi: 10.1021/acs.jmedchem.1c01964. Epub 2022 Feb 3. J Med Chem. 2022. PMID: 35113556 Free PMC article.

5

Open-label phase 1b pilot study to assess the antiviral efficacy of simvastatin combined with sertraline in chronic hepatitis C patients.

Patel K, Lim SG, Cheng CW, Lawitz E, Tillmann HL, Chopra N, Altmeyer R, Randle JC, McHutchison JG. Patel K, et al. Antivir Ther. 2011;16(8):1341-6. doi: 10.3851/IMP1898. Antivir Ther. 2011. PMID: 22155916 Clinical Trial.

6

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.

Adiwijaya BS, Herrmann E, Hare B, Kieffer T, Lin C, Kwong AD, Garg V, Randle JC, Sarrazin C, Zeuzem S, Caron PR. Adiwijaya BS, et al. PLoS Comput Biol. 2010 Apr 15;6(4):e1000745. doi: 10.1371/journal.pcbi.1000745. PLoS Comput Biol. 2010. PMID: 20419154 Free PMC article.

7

(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18.

Wannamaker W, Davies R, Namchuk M, Pollard J, Ford P, Ku G, Decker C, Charifson P, Weber P, Germann UA, Kuida K, Randle JC. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16. doi: 10.1124/jpet.106.111344. Epub 2007 Feb 8. J Pharmacol Exp Ther. 2007. PMID: 17289835

8

Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy.

Ravizza T, Lucas SM, Balosso S, Bernardino L, Ku G, Noé F, Malva J, Randle JC, Allan S, Vezzani A. Ravizza T, et al. Epilepsia. 2006 Jul;47(7):1160-8. doi: 10.1111/j.1528-1167.2006.00590.x. Epilepsia. 2006. PMID: 16886979 Free article.

9

IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients.

Stack JH, Beaumont K, Larsen PD, Straley KS, Henkel GW, Randle JC, Hoffman HM. Stack JH, et al. J Immunol. 2005 Aug 15;175(4):2630-4. doi: 10.4049/jimmunol.175.4.2630. J Immunol. 2005. PMID: 16081838

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