Dowty ME - Search Results

1

Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective.

Reddy MB, Cabalu TD, de Zwart L, Ramsden D, Dowty ME, Taskar KS, Badée J, Bolleddula J, Boulu L, Fu Q, Kotsuma M, Leblanc AF, Lewis G, Liang G, Parrott N, Pilla Reddy V, Prakash C, Shah K, Umehara K, Mukherjee D, Rehmel J, Hariparsad N. Reddy MB, et al. Among authors: dowty me. Clin Pharmacol Ther. 2024 Oct 18. doi: 10.1002/cpt.3477. Online ahead of print. Clin Pharmacol Ther. 2024. PMID: 39422118 Review.

2

Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.

Hariparsad N, Ramsden D, Taskar K, Badée J, Venkatakrishnan K, Reddy MB, Cabalu T, Mukherjee D, Rehmel J, Bolleddula J, Emami Riedmaier A, Prakash C, Chanteux H, Mao J, Umehara K, Shah K, De Zwart L, Dowty M, Kotsuma M, Li M, Pilla Reddy V, McGinnity DF, Parrott N. Hariparsad N, et al. Clin Pharmacol Ther. 2022 Oct;112(4):770-781. doi: 10.1002/cpt.2503. Epub 2021 Dec 24. Clin Pharmacol Ther. 2022. PMID: 34862964

3

Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug-Drug Interactions or in Special Populations: An Example Using Tofacitinib.

Tse S, Dowty ME, Menon S, Gupta P, Krishnaswami S. Tse S, et al. Among authors: dowty me. J Clin Pharmacol. 2020 Dec;60(12):1617-1628. doi: 10.1002/jcph.1679. Epub 2020 Jun 27. J Clin Pharmacol. 2020. PMID: 32592424 Free PMC article.

4

The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.

Dowty ME, Lin J, Ryder TF, Wang W, Walker GS, Vaz A, Chan GL, Krishnaswami S, Prakash C. Dowty ME, et al. Drug Metab Dispos. 2014 Apr;42(4):759-73. doi: 10.1124/dmd.113.054940. Epub 2014 Jan 24. Drug Metab Dispos. 2014. PMID: 24464803

5

Integrating Clinical Variability into PBPK Models for Virtual Bioequivalence of Single and Multiple Doses of Tofacitinib Modified-Release Dosage Form.

Purohit V, Sagawa K, Hsu HJ, Kushner J, Dowty ME, Tse S, Lin J, Blanchard A, Mukherjee A, Le V, Chang C. Purohit V, et al. Among authors: dowty me. Clin Pharmacol Ther. 2024 Oct;116(4):996-1004. doi: 10.1002/cpt.3313. Epub 2024 May 26. Clin Pharmacol Ther. 2024. PMID: 38797995 Clinical Trial.

6

Model-Informed Development and Registration of a Once-Daily Regimen of Extended-Release Tofacitinib.

Lamba M, Hutmacher MM, Furst DE, Dikranian A, Dowty ME, Conrado D, Stock T, Nduaka C, Cook J, Krishnaswami S. Lamba M, et al. Among authors: dowty me. Clin Pharmacol Ther. 2017 Jun;101(6):745-753. doi: 10.1002/cpt.576. Epub 2017 Feb 9. Clin Pharmacol Ther. 2017. PMID: 27859030 Free PMC article.

7

Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Wang EQ, Le V, O'Gorman M, Tripathy S, Dowty ME, Wang L, Malhotra BK. Wang EQ, et al. Among authors: dowty me. J Clin Pharmacol. 2021 Oct;61(10):1311-1323. doi: 10.1002/jcph.1858. Epub 2021 Apr 17. J Clin Pharmacol. 2021. PMID: 33749838 Free PMC article. Clinical Trial.

8

Evaluation of the Effect of Abrocitinib on Drug Transporters by Integrated Use of Probe Drugs and Endogenous Biomarkers.

Vourvahis M, Byon W, Chang C, Le V, Diehl A, Graham D, Tripathy S, Raha N, Luo L, Mathialagan S, Dowty M, Rodrigues AD, Malhotra B. Vourvahis M, et al. Clin Pharmacol Ther. 2022 Sep;112(3):665-675. doi: 10.1002/cpt.2594. Epub 2022 May 9. Clin Pharmacol Ther. 2022. PMID: 35344588 Free PMC article. Clinical Trial.

9

Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis.

Dowty ME, Jesson MI, Ghosh S, Lee J, Meyer DM, Krishnaswami S, Kishore N. Dowty ME, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):165-73. doi: 10.1124/jpet.113.209304. Epub 2013 Nov 11. J Pharmacol Exp Ther. 2014. PMID: 24218541 Clinical Trial.

10

Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Wang EQ, Le V, Winton JA, Tripathy S, Raje S, Wang L, Dowty ME, Malhotra BK. Wang EQ, et al. Among authors: dowty me. J Clin Pharmacol. 2022 Apr;62(4):505-519. doi: 10.1002/jcph.1980. Epub 2022 Feb 15. J Clin Pharmacol. 2022. PMID: 34637151 Free PMC article. Clinical Trial.

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