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Page 1
Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective.
Reddy MB, Cabalu TD, de Zwart L, Ramsden D, Dowty ME, Taskar KS, Badée J, Bolleddula J, Boulu L, Fu Q, Kotsuma M, Leblanc AF, Lewis G, Liang G, Parrott N, Pilla Reddy V, Prakash C, Shah K, Umehara K, Mukherjee D, Rehmel J, Hariparsad N. Reddy MB, et al. Among authors: leblanc af. Clin Pharmacol Ther. 2024 Oct 18. doi: 10.1002/cpt.3477. Online ahead of print. Clin Pharmacol Ther. 2024. PMID: 39422118 Review.
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
Petersson C, Zhou X, Berghausen J, Cebrian D, Davies M, DeMent K, Eddershaw P, Riedmaier AE, Leblanc AF, Manveski N, Marathe P, Mavroudis PD, McDougall R, Parrott N, Reichel A, Rotter C, Tess D, Volak LP, Xiao G, Yang Z, Baker J. Petersson C, et al. Among authors: leblanc af. AAPS J. 2022 Jul 19;24(5):85. doi: 10.1208/s12248-022-00735-9. AAPS J. 2022. PMID: 35854202 Review.
Targeting a xenobiotic transporter to ameliorate vincristine-induced sensory neuropathy.
Li Y, Drabison T, Nepal M, Ho RH, Leblanc AF, Gibson AA, Jin Y, Yang W, Huang KM, Uddin ME, Chen M, DiGiacomo DF, Chen X, Razzaq S, Tonniges JR, McTigue DM, Mims AS, Lustberg MB, Wang Y, Hummon AB, Evans WE, Baker SD, Cavaletti G, Sparreboom A, Hu S. Li Y, et al. Among authors: leblanc af. JCI Insight. 2023 Jul 24;8(14):e164646. doi: 10.1172/jci.insight.164646. JCI Insight. 2023. PMID: 37347545 Free PMC article.
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Huang KM, Leblanc AF, Uddin ME, Kim JY, Chen M, Eisenmann ED, Gibson AA, Li Y, Hong KW, DiGiacomo D, Xia SH, Alberti P, Chiorazzi A, Housley SN, Cope TC, Sprowl JA, Wang J, Loprinzi CL, Noonan A, Lustberg MB, Cavaletti G, Pabla N, Hu S, Sparreboom A. Huang KM, et al. Among authors: leblanc af. J Clin Invest. 2020 Sep 1;130(9):4601-4606. doi: 10.1172/JCI136796. J Clin Invest. 2020. PMID: 32484793 Free PMC article.
Murine Pharmacokinetic Studies.
Leblanc AF, Huang KM, Uddin ME, Anderson JT, Chen M, Hu S. Leblanc AF, et al. Bio Protoc. 2018 Oct 20;8(20):e3056. doi: 10.21769/BioProtoc.3056. Bio Protoc. 2018. PMID: 31106235 Free PMC article.
OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.
Leblanc AF, Sprowl JA, Alberti P, Chiorazzi A, Arnold WD, Gibson AA, Hong KW, Pioso MS, Chen M, Huang KM, Chodisetty V, Costa O, Florea T, de Bruijn P, Mathijssen RH, Reinbolt RE, Lustberg MB, Sucheston-Campbell LE, Cavaletti G, Sparreboom A, Hu S. Leblanc AF, et al. J Clin Invest. 2018 Feb 1;128(2):816-825. doi: 10.1172/JCI96160. Epub 2018 Jan 16. J Clin Invest. 2018. PMID: 29337310 Free PMC article.
Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
Hu S, Leblanc AF, Gibson AA, Hong KW, Kim JY, Janke LJ, Li L, Vasilyeva A, Finkelstein DB, Sprowl JA, Sweet DH, Schlatter E, Ciarimboli G, Schellens J, Baker SD, Pabla N, Sparreboom A. Hu S, et al. Among authors: leblanc af. Clin Transl Sci. 2017 Sep;10(5):412-420. doi: 10.1111/cts.12480. Epub 2017 Jul 8. Clin Transl Sci. 2017. PMID: 28689374 Free PMC article.
13 results