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153 results

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Page 1
Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice.
Dos Santos C, Cambraia A, Shrestha S, Cutler M, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, Arrojo E Drigo R. Dos Santos C, et al. Among authors: macdonald pe. Nat Commun. 2024 Oct 21;15(1):9063. doi: 10.1038/s41467-024-53127-2. Nat Commun. 2024. PMID: 39433757 Free PMC article.
Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.
Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Cutler M, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, E Drigo RA. Dos Santos C, et al. Among authors: macdonald pe. bioRxiv [Preprint]. 2023 Aug 24:2023.08.23.554369. doi: 10.1101/2023.08.23.554369. bioRxiv. 2023. PMID: 37662336 Free PMC article. Preprint.
Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.
Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Cutler M, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, Drigo RAE. Dos Santos C, et al. Among authors: macdonald pe. Res Sq [Preprint]. 2023 Sep 20:rs.3.rs-3311459. doi: 10.21203/rs.3.rs-3311459/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Oct 21;15(1):9063. doi: 10.1038/s41467-024-53127-2 PMID: 37790446 Free PMC article. Updated. Preprint.
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress.
Shrestha S, Erikson G, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Dos Santos C, Shokhirev M, Cartailler JP, Hetzer MW, MacDonald PE, Arrojo E Drigo R. Shrestha S, et al. Among authors: macdonald pe. Sci Adv. 2022 Oct 7;8(40):eabo3932. doi: 10.1126/sciadv.abo3932. Epub 2022 Oct 5. Sci Adv. 2022. PMID: 36197983 Free PMC article.
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. Dai XQ, et al. Among authors: macdonald pe. Cell Metab. 2022 Feb 1;34(2):256-268.e5. doi: 10.1016/j.cmet.2021.12.021. Cell Metab. 2022. PMID: 35108513 Free PMC article.
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Skovsø S, et al. Among authors: macdonald pe. Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8. Nat Commun. 2022. PMID: 35136059 Free PMC article.
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
Lin H, Suzuki K, Smith N, Li X, Nalbach L, Fuentes S, Spigelman AF, Dai XQ, Bautista A, Ferdaoussi M, Aggarwal S, Pepper AR, Roma LP, Ampofo E, Li WH, MacDonald PE. Lin H, et al. Among authors: macdonald pe. Nat Commun. 2024 Jan 6;15(1):334. doi: 10.1038/s41467-023-44589-x. Nat Commun. 2024. PMID: 38184650 Free PMC article.
Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.
Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E. Bozadjieva N, et al. Among authors: macdonald pe. J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6. J Clin Invest. 2017. PMID: 29106387 Free PMC article.
153 results