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Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.
Barthelmes J, de Bazo AM, Pewzner-Jung Y, Schmitz K, Mayer CA, Foerch C, Eberle M, Tafferner N, Ferreirós N, Henke M, Geisslinger G, Futerman AH, Grösch S, Schiffmann S. Barthelmes J, et al. Among authors: schiffmann s. Brain Behav Immun. 2015 May;46:280-92. doi: 10.1016/j.bbi.2015.02.010. Epub 2015 Feb 16. Brain Behav Immun. 2015. PMID: 25697397
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Eberle M, Ebel P, Mayer CA, Barthelmes J, Tafferner N, Ferreiros N, Ulshöfer T, Henke M, Foerch C, de Bazo AM, Grösch S, Geisslinger G, Willecke K, Schiffmann S. Eberle M, et al. Among authors: schiffmann s. Immunol Cell Biol. 2015 Oct;93(9):825-36. doi: 10.1038/icb.2015.47. Epub 2015 Apr 2. Immunol Cell Biol. 2015. PMID: 25833068
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.
Kurz J, Brunkhorst R, Foerch C, Blum L, Henke M, Gabriel L, Ulshöfer T, Ferreirós N, Parnham MJ, Geisslinger G, Schiffmann S. Kurz J, et al. Among authors: schiffmann s. Clin Sci (Lond). 2018 Aug 17;132(17):1963-1976. doi: 10.1042/CS20180506. Print 2018 Sep 14. Clin Sci (Lond). 2018. PMID: 30219773
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing.
Bode E, Heinrich AK, Hirschmann M, Abebew D, Shi YN, Vo TD, Wesche F, Shi YM, Grün P, Simonyi S, Keller N, Engel Y, Wenski S, Bennet R, Beyer S, Bischoff I, Buaya A, Brandt S, Cakmak I, Çimen H, Eckstein S, Frank D, Fürst R, Gand M, Geisslinger G, Hazir S, Henke M, Heermann R, Lecaudey V, Schäfer W, Schiffmann S, Schüffler A, Schwenk R, Skaljac M, Thines E, Thines M, Ulshöfer T, Vilcinskas A, Wichelhaus TA, Bode HB. Bode E, et al. Among authors: schiffmann s. Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18957-18963. doi: 10.1002/anie.201910563. Epub 2019 Dec 12. Angew Chem Int Ed Engl. 2019. PMID: 31693786 Free PMC article.
The immunomodulatory potential of the arylmethylaminosteroid sc1o.
Blum L, Ulshöfer T, Henke M, Krieg R, Berneburg I, Geisslinger G, Becker K, Parnham MJ, Schiffmann S. Blum L, et al. Among authors: schiffmann s. J Mol Med (Berl). 2021 Feb;99(2):261-272. doi: 10.1007/s00109-020-02024-4. Epub 2020 Dec 17. J Mol Med (Berl). 2021. PMID: 33330947 Free PMC article.
252 results