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Phase I First-in-Human Dose Escalation Study of the oral Casein Kinase 1α and Cyclin Dependent Kinase 7/9 inhibitor BTX-A51 in advanced MDS and AML.
Ball B, Xiao W, Borthakur G, Nguyen LXT, Valerio M, Venkatachalam A, Marcucci G, Stein A, Thai DL, Cook D, Chan K, Persaud S, Levine R, Abdel-Wahab O, Ben-Neriah Y, Stein E. Ball B, et al. Among authors: nguyen lxt. Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-4954060. doi: 10.21203/rs.3.rs-4954060/v1. Res Sq. 2024. PMID: 39483885 Free PMC article. Preprint.
Homoharringtonine synergizes with venetoclax in early T cell progenitor acute lymphoblastic leukemia: Bench and bed.
Suo S, Sun S, Nguyen LXT, Qian J, Li F, Zhao D, Yu W, Lou Y, Zhu H, Tong H, Yang M, Huang X, Zhao S, Qiao J, Liang C, Wang H, Zhang Y, Zhang X, Hoang DH, Chen F, Kang H, Valerio M, Sun J, Ghoda L, Li L, Marcucci G, Zhang B, Jin J. Suo S, et al. Among authors: nguyen lxt. Med. 2024 Aug 10:S2666-6340(24)00300-3. doi: 10.1016/j.medj.2024.07.018. Online ahead of print. Med. 2024. PMID: 39151422
IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells.
Zhang Y, Park M, Ghoda LY, Zhao D, Valerio M, Nafie E, Gonzalez A, Ly K, Parcutela B, Choi H, Gong X, Chen F, Harada K, Chen Z, Nguyen LXT, Pichiorri F, Chen J, Song J, Forman SJ, Amanam I, Zhang B, Jin J, Williams JC, Marcucci G. Zhang Y, et al. Among authors: nguyen lxt. J Hematol Oncol. 2024 Aug 14;17(1):67. doi: 10.1186/s13045-024-01586-x. J Hematol Oncol. 2024. PMID: 39143574 Free PMC article.
OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia.
Kang H, Hoang DH, Valerio M, Pathak K, Zhang L, Buettner R, Chen F, Estrella K, Graff W, Li Z, Xie J, Horne D, Kuo YH, Zhang B, Pirrotte P, Nguyen LXT, Marcucci G. Kang H, et al. Among authors: nguyen lxt. Leukemia. 2024 Mar;38(3):657-662. doi: 10.1038/s41375-024-02146-5. Epub 2024 Jan 17. Leukemia. 2024. PMID: 38233463 Free PMC article. No abstract available.
Spred1 deficit promotes treatment resistance and transformation of chronic phase CML.
Qiao J, Liang C, Zhao D, Nguyen LXT, Chen F, Suo S, Hoang DH, Pellicano F, Rodriguez IR, Elhajmoussa Y, Ghoda L, Yoshimura A, Stein AS, Ali H, Koller P, Perrotti D, Copland M, Han A, Zhang BA, Marcucci G. Qiao J, et al. Among authors: nguyen lxt. Leukemia. 2022 Feb;36(2):492-506. doi: 10.1038/s41375-021-01423-x. Epub 2021 Sep 25. Leukemia. 2022. PMID: 34564700 Free PMC article.
Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML.
Zhang B, Nguyen LXT, Zhao D, Frankhouser DE, Wang H, Hoang DH, Qiao J, Abundis C, Brehove M, Su YL, Feng Y, Stein A, Ghoda L, Dorrance A, Perrotti D, Chen Z, Han A, Pichiorri F, Jin J, Jovanovic-Talisman T, Caligiuri MA, Kuo CJ, Yoshimura A, Li L, Rockne RC, Kortylewski M, Zheng Y, Carlesso N, Kuo YH, Marcucci G. Zhang B, et al. Among authors: nguyen lxt. J Hematol Oncol. 2021 Aug 9;14(1):122. doi: 10.1186/s13045-021-01133-y. J Hematol Oncol. 2021. PMID: 34372909 Free PMC article.
8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia.
Guo J, Buettner R, Du L, Li Z, Liu W, Su R, Chen Z, Che Y, Zhang Y, Ma R, Nguyen LXT, Moore RE, Khyatiben P, Chen MH, Patrick P, Wu X, Marcucci G, Wang L, Horne D, Chen J, Yang Y, Rosen ST. Guo J, et al. Among authors: nguyen lxt. Leukemia. 2024 Jun;38(6):1236-1245. doi: 10.1038/s41375-024-02222-w. Epub 2024 Apr 20. Leukemia. 2024. PMID: 38643304 Free PMC article.
27 results