Burke JE - Search Results

1

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.

Gong GQ, Masson GR, Lee WJ, Dickson JM, Kendall JD, Rathinaswamy MK, Buchanan CM, Middleditch M, Owen B, Spicer JA, Rewcastle GW, Denny WA, Burke JE, Shepherd PR, Williams RL, Flanagan JU. Gong GQ, et al. Among authors: burke je. Biochem J. 2024 Nov 1:BCJ20240479. doi: 10.1042/BCJ20240479. Online ahead of print. Biochem J. 2024. PMID: 39485310

2

Synergy in activating class I PI3Ks.

Burke JE, Williams RL. Burke JE, et al. Trends Biochem Sci. 2015 Feb;40(2):88-100. doi: 10.1016/j.tibs.2014.12.003. Epub 2015 Jan 5. Trends Biochem Sci. 2015. PMID: 25573003 Review.

3

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

Masson GR, Perisic O, Burke JE, Williams RL. Masson GR, et al. Among authors: burke je. Biochem J. 2016 Jan 15;473(2):135-44. doi: 10.1042/BJ20150931. Epub 2015 Nov 2. Biochem J. 2016. PMID: 26527737 Free PMC article.

4

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Burke JE, Perisic O, Masson GR, Vadas O, Williams RL. Burke JE, et al. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. doi: 10.1073/pnas.1205508109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949682 Free PMC article.

5

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

Burke JE, Williams RL. Burke JE, et al. Adv Biol Regul. 2013 Jan;53(1):97-110. doi: 10.1016/j.jbior.2012.09.005. Epub 2012 Sep 13. Adv Biol Regul. 2013. PMID: 23194976 Free PMC article.

6

Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease.

Rathinaswamy MK, Burke JE. Rathinaswamy MK, et al. Among authors: burke je. Adv Biol Regul. 2020 Jan;75:100657. doi: 10.1016/j.jbior.2019.100657. Epub 2019 Sep 28. Adv Biol Regul. 2020. PMID: 31611073 Review.

7

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.

Ziemba BP, Burke JE, Masson G, Williams RL, Falke JJ. Ziemba BP, et al. Among authors: burke je. Biophys J. 2016 Apr 26;110(8):1811-1825. doi: 10.1016/j.bpj.2016.03.001. Biophys J. 2016. PMID: 27119641 Free PMC article.

8

Rathinaswamy MK, Gaieb Z, Fleming KD, Borsari C, Harris NJ, Moeller BE, Wymann MP, Amaro RE, Burke JE. Rathinaswamy MK, et al. Among authors: burke je. Elife. 2021 Mar 4;10:e64691. doi: 10.7554/eLife.64691. Elife. 2021. PMID: 33661099 Free PMC article.

9

Connecting with an old partner in a new way.

Burke JE, Williams RL. Burke JE, et al. Cancer Cell. 2013 May 13;23(5):559-61. doi: 10.1016/j.ccr.2013.04.023. Cancer Cell. 2013. PMID: 23680139 Free article.

10

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.

Clarke JH, Giudici ML, Burke JE, Williams RL, Maloney DJ, Marugan J, Irvine RF. Clarke JH, et al. Among authors: burke je. Biochem J. 2015 Mar 1;466(2):359-67. doi: 10.1042/BJ20141333. Biochem J. 2015. PMID: 25495341 Free PMC article.

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