Rewcastle GW - Search Results

1

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.

Gong GQ, Masson GR, Lee WJ, Dickson JM, Kendall JD, Rathinaswamy MK, Buchanan CM, Middleditch M, Owen B, Spicer JA, Rewcastle GW, Denny WA, Burke JE, Shepherd PR, Williams RL, Flanagan JU. Gong GQ, et al. Among authors: rewcastle gw. Biochem J. 2024 Nov 1:BCJ20240479. doi: 10.1042/BCJ20240479. Online ahead of print. Biochem J. 2024. PMID: 39485310

2

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

Chaussade C, Rewcastle GW, Kendall JD, Denny WA, Cho K, Grønning LM, Chong ML, Anagnostou SH, Jackson SP, Daniele N, Shepherd PR. Chaussade C, et al. Among authors: rewcastle gw. Biochem J. 2007 Jun 15;404(3):449-58. doi: 10.1042/BJ20070003. Biochem J. 2007. PMID: 17362206 Free PMC article.

3

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.

Jamieson S, Flanagan JU, Kolekar S, Buchanan C, Kendall JD, Lee WJ, Rewcastle GW, Denny WA, Singh R, Dickson J, Baguley BC, Shepherd PR. Jamieson S, et al. Among authors: rewcastle gw. Biochem J. 2011 Aug 15;438(1):53-62. doi: 10.1042/BJ20110502. Biochem J. 2011. PMID: 21668414 Free PMC article.

4

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo.

Smith GC, Ong WK, Rewcastle GW, Kendall JD, Han W, Shepherd PR. Smith GC, et al. Among authors: rewcastle gw. Biochem J. 2012 Feb 15;442(1):161-9. doi: 10.1042/BJ20111913. Biochem J. 2012. PMID: 22142257 Free PMC article.

5

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

Gong GQ, Kendall JD, Dickson JMJ, Rewcastle GW, Buchanan CM, Denny WA, Shepherd PR, Flanagan JU. Gong GQ, et al. Among authors: rewcastle gw. Biochem J. 2017 Jun 26;474(13):2261-2276. doi: 10.1042/BCJ20161098. Biochem J. 2017. PMID: 28526744

6

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

Kendall JD, Rewcastle GW, Frederick R, Mawson C, Denny WA, Marshall ES, Baguley BC, Chaussade C, Jackson SP, Shepherd PR. Kendall JD, et al. Among authors: rewcastle gw. Bioorg Med Chem. 2007 Dec 15;15(24):7677-87. doi: 10.1016/j.bmc.2007.08.062. Epub 2007 Sep 4. Bioorg Med Chem. 2007. PMID: 17869522

7

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

Chaussade C, Cho K, Mawson C, Rewcastle GW, Shepherd PR. Chaussade C, et al. Among authors: rewcastle gw. Biochem Biophys Res Commun. 2009 Apr 17;381(4):577-81. doi: 10.1016/j.bbrc.2009.02.081. Epub 2009 Feb 20. Biochem Biophys Res Commun. 2009. PMID: 19233141

8

High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds.

Wang J, Gong GQ, Zhou Y, Lee WJ, Buchanan CM, Denny WA, Rewcastle GW, Kendall JD, Dickson JMJ, Flanagan JU, Shepherd PR, Yang DH, Wang MW. Wang J, et al. Among authors: rewcastle gw. Acta Pharmacol Sin. 2018 Nov;39(11):1816-1822. doi: 10.1038/s41401-018-0057-z. Epub 2018 Jul 10. Acta Pharmacol Sin. 2018. PMID: 29991713 Free PMC article.

9

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

Frédérick R, Mawson C, Kendall JD, Chaussade C, Rewcastle GW, Shepherd PR, Denny WA. Frédérick R, et al. Among authors: rewcastle gw. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5842-7. doi: 10.1016/j.bmcl.2009.08.087. Epub 2009 Aug 29. Bioorg Med Chem Lett. 2009. PMID: 19748269

10

Evidence for a role for the p110-alpha isoform of PI3K in skeletal function.

Grey A, Chaussade C, Empson V, Lin JM, Watson M, O'Sullivan S, Rewcastle G, Naot D, Cornish J, Shepherd P. Grey A, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):564-9. doi: 10.1016/j.bbrc.2009.11.099. Epub 2009 Nov 24. Biochem Biophys Res Commun. 2010. PMID: 19931507

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