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270 results

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Page 1
Pharmacokinetics and Tolerability of the Novel Myeloperoxidase Inhibitor Mitiperstat in Healthy Japanese and Chinese Volunteers.
Sunnåker M, Bhattacharya C, Nelander K, Aurell M, Heijer M, Collén A, Han D, Holden J, Trebski M, Garkaviy P, Ericsson H. Sunnåker M, et al. Among authors: aurell m. Clin Drug Investig. 2024 Nov;44(11):863-874. doi: 10.1007/s40261-024-01402-x. Epub 2024 Nov 4. Clin Drug Investig. 2024. PMID: 39495467 Free PMC article. Clinical Trial.
Rationale and design of ENDEAVOR: A sequential phase 2b-3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.
Lund LH, Lam CSP, Pizzato PE, Gabrielsen A, Michaëlsson E, Nelander K, Ericsson H, Holden J, Folkvaljon F, Mattsson A, Collén A, Aurell M, Whatling C, Baldus S, Drelich G, Goudev A, Merkely B, Bergh N, Shah SJ. Lund LH, et al. Among authors: aurell m. Eur J Heart Fail. 2023 Sep;25(9):1696-1707. doi: 10.1002/ejhf.2977. Epub 2023 Aug 22. Eur J Heart Fail. 2023. PMID: 37470101 Free PMC article. Clinical Trial.
A drug-drug interaction study and physiologically based pharmacokinetic modelling to assess the effect of an oral 5-lipoxygenase activating protein inhibitor on the pharmacokinetics of oral midazolam.
Knöchel J, Panduga V, Nelander K, Heijer M, Lindstedt EL, Ali H, Aurell M, Ödesjö H, Forte P, Connolly K, Ericsson H, MacPhee I. Knöchel J, et al. Among authors: aurell m. Br J Clin Pharmacol. 2024 Sep;90(9):2180-2187. doi: 10.1111/bcp.16131. Epub 2024 Jun 3. Br J Clin Pharmacol. 2024. PMID: 38830622 Clinical Trial.
A Phase 2a, Double-Blind, Placebo-controlled Randomized Trial of Inhaled TLR9 Agonist AZD1419 in Asthma.
Psallidas I, Backer V, Kuna P, Palmér R, Necander S, Aurell M, Korsback K, Taib Z, Hashemi M, Gustafson P, Asimus S, Delaney S, Pardali K, Jiang F, Almquist J, Jackson S, Coffman RL, Keeling D, Sethi T. Psallidas I, et al. Among authors: aurell m. Am J Respir Crit Care Med. 2021 Feb 1;203(3):296-306. doi: 10.1164/rccm.202001-0133OC. Am J Respir Crit Care Med. 2021. PMID: 32809843 Clinical Trial.
INEXAS: A Phase 2 Randomized Trial of On-demand Inhaled Interferon Beta-1a in Severe Asthmatics.
McCrae C, Olsson M, Gustafson P, Malmgren A, Aurell M, Fagerås M, Da Silva CA, Cavallin A, Paraskos J, Karlsson K, Wingren C, Monk P, Marsden R, Harrison T. McCrae C, et al. Among authors: aurell m. Clin Exp Allergy. 2021 Feb;51(2):273-283. doi: 10.1111/cea.13765. Epub 2020 Nov 3. Clin Exp Allergy. 2021. PMID: 33091192 Free PMC article. Clinical Trial.
Model-based drug discovery: implementation and impact.
Visser SA, Aurell M, Jones RD, Schuck VJ, Egnell AC, Peters SA, Brynne L, Yates JW, Jansson-Löfmark R, Tan B, Cooke M, Barry ST, Hughes A, Bredberg U. Visser SA, et al. Among authors: aurell m. Drug Discov Today. 2013 Aug;18(15-16):764-75. doi: 10.1016/j.drudis.2013.05.012. Epub 2013 May 29. Drug Discov Today. 2013. PMID: 23726890 Review.
270 results