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Page 1
Effects of Cimetidine and Dolutegravir on the Endogenous Drug-Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers.
Koishikawa T, Fujiwara K, Taskar K, Zamek-Gliszczynski MJ, Yoshida K, Chu X, Hirabayashi H, Mao J, Rockich K, Takashima T, Yamaura Y, Lai Y, Tomoda Y, Kito T, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. Koishikawa T, et al. Among authors: takashima t. Clin Pharmacol Ther. 2024 Nov 5. doi: 10.1002/cpt.3482. Online ahead of print. Clin Pharmacol Ther. 2024. PMID: 39497599
Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions.
Mochizuki T, Zamek-Gliszczynski MJ, Yoshida K, Mao J, Taskar K, Hirabayashi H, Chu X, Lai Y, Takashima T, Rockich K, Yamaura Y, Fujiwara K, Mizuno T, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. Mochizuki T, et al. Among authors: takashima t. Clin Pharmacol Ther. 2022 Jun;111(6):1315-1323. doi: 10.1002/cpt.2584. Epub 2022 Apr 11. Clin Pharmacol Ther. 2022. PMID: 35292967 Free PMC article.
Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs.
Mochizuki T, Aoki Y, Yoshikado T, Yoshida K, Lai Y, Hirabayashi H, Yamaura Y, Rockich K, Taskar K, Takashima T, Chu X, Zamek-Gliszczynski MJ, Mao J, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. Mochizuki T, et al. Among authors: takashima t. Clin Transl Sci. 2022 Jun;15(6):1519-1531. doi: 10.1111/cts.13272. Epub 2022 May 2. Clin Transl Sci. 2022. PMID: 35421902 Free PMC article.
Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats.
Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y. Shingaki T, et al. Among authors: takashima t. J Pharmacol Exp Ther. 2013 Oct;347(1):193-202. doi: 10.1124/jpet.113.206425. Epub 2013 Aug 7. J Pharmacol Exp Ther. 2013. PMID: 23926287
The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.
Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y, Watanabe Y. Hume WE, et al. Among authors: takashima t. Bioorg Med Chem. 2013 Dec 15;21(24):7584-90. doi: 10.1016/j.bmc.2013.10.041. Epub 2013 Nov 1. Bioorg Med Chem. 2013. PMID: 24238901
Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir.
Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y. Takashima T, et al. J Nucl Med. 2011 Jun;52(6):950-7. doi: 10.2967/jnumed.110.083949. Epub 2011 May 13. J Nucl Med. 2011. PMID: 21571790 Free article.
Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.
Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y. Kusuhara H, et al. Among authors: takashima t. Drug Metab Pharmacokinet. 2017 Dec;32(6):293-300. doi: 10.1016/j.dmpk.2017.09.003. Epub 2017 Sep 21. Drug Metab Pharmacokinet. 2017. PMID: 29137842 Clinical Trial.
1,072 results