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Page 1
Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.
Jang E, Hoxha K, Mozier D, Insana A, Farber E, Changolkar L, Zhang B, Chio TI, Crowe A, Chen R, Mercken M, Lee EB, Luk KC, Brunden KR, Lee VM, Xu H. Jang E, et al. Among authors: changolkar l. J Neurosci. 2024 Nov 27;44(48):e0877242024. doi: 10.1523/JNEUROSCI.0877-24.2024. J Neurosci. 2024. PMID: 39500576
GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.
Gibbons GS, Banks RA, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM. Gibbons GS, et al. Among authors: changolkar l. J Neurosci. 2017 Nov 22;37(47):11485-11494. doi: 10.1523/JNEUROSCI.2393-17.2017. Epub 2017 Oct 6. J Neurosci. 2017. PMID: 28986461 Free PMC article.
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics.
Xu H, O'Reilly M, Gibbons GS, Changolkar L, McBride JD, Riddle DM, Zhang B, Stieber A, Nirschl J, Kim SJ, Hoxha KH, Brunden KR, Schellenberg GD, Trojanowski JQ, Lee VM. Xu H, et al. Among authors: changolkar l. Acta Neuropathol. 2021 Feb;141(2):193-215. doi: 10.1007/s00401-020-02253-4. Epub 2021 Jan 1. Acta Neuropathol. 2021. PMID: 33385254 Free PMC article.
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
Xu H, Qiu Q, Hu P, Hoxha K, Jang E, O'Reilly M, Kim C, He Z, Marotta N, Changolkar L, Zhang B, Wu H, Schellenberg GD, Kraemer B, Luk KC, Lee EB, Trojanowski JQ, Brunden KR, Lee VM. Xu H, et al. Among authors: changolkar l. Acta Neuropathol. 2024 Mar 12;147(1):55. doi: 10.1007/s00401-024-02703-3. Acta Neuropathol. 2024. PMID: 38472475 Free PMC article.
Transmission of tauopathy strains is independent of their isoform composition.
He Z, McBride JD, Xu H, Changolkar L, Kim SJ, Zhang B, Narasimhan S, Gibbons GS, Guo JL, Kozak M, Schellenberg GD, Trojanowski JQ, Lee VM. He Z, et al. Among authors: changolkar l. Nat Commun. 2020 Jan 7;11(1):7. doi: 10.1038/s41467-019-13787-x. Nat Commun. 2020. PMID: 31911587 Free PMC article.
30 results