Luk KC - Search Results

1

Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.

Jang E, Hoxha K, Mozier D, Insana A, Farber E, Changolkar L, Zhang B, Chio TI, Crowe A, Chen R, Mercken M, Lee EB, Luk KC, Brunden KR, Lee VM, Xu H. Jang E, et al. Among authors: luk kc. J Neurosci. 2024 Nov 27;44(48):e0877242024. doi: 10.1523/JNEUROSCI.0877-24.2024. J Neurosci. 2024. PMID: 39500576

2

Modeling Lewy pathology propagation in Parkinson's disease.

Luk KC, Lee VM. Luk KC, et al. Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1(0 1):S85-7. doi: 10.1016/S1353-8020(13)70022-1. Parkinsonism Relat Disord. 2014. PMID: 24262196 Free PMC article. Review.

3

MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.

Xu H, Qiu Q, Hu P, Hoxha K, Jang E, O'Reilly M, Kim C, He Z, Marotta N, Changolkar L, Zhang B, Wu H, Schellenberg GD, Kraemer B, Luk KC, Lee EB, Trojanowski JQ, Brunden KR, Lee VM. Xu H, et al. Among authors: luk kc. Acta Neuropathol. 2024 Mar 12;147(1):55. doi: 10.1007/s00401-024-02703-3. Acta Neuropathol. 2024. PMID: 38472475 Free PMC article.

4

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.

Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Luk KC, et al. J Exp Med. 2012 May 7;209(5):975-86. doi: 10.1084/jem.20112457. Epub 2012 Apr 16. J Exp Med. 2012. PMID: 22508839 Free PMC article.

5

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

Volpicelli-Daley LA, Luk KC, Lee VM. Volpicelli-Daley LA, et al. Among authors: luk kc. Nat Protoc. 2014 Sep;9(9):2135-46. doi: 10.1038/nprot.2014.143. Epub 2014 Aug 14. Nat Protoc. 2014. PMID: 25122523 Free PMC article.

6

Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils.

Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC. Zhang B, et al. Among authors: luk kc. Methods Mol Biol. 2019;1948:45-57. doi: 10.1007/978-1-4939-9124-2_5. Methods Mol Biol. 2019. PMID: 30771169 Free PMC article.

7

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.

Henderson MX, Covell DJ, Chung CH, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden KR, Lee VMY, Luk KC. Henderson MX, et al. Among authors: luk kc. Neurobiol Dis. 2020 Mar;136:104712. doi: 10.1016/j.nbd.2019.104712. Epub 2019 Dec 16. Neurobiol Dis. 2020. PMID: 31837422 Free PMC article.

8

Cell-to-Cell Transmission of Tau and α-Synuclein.

Uemura N, Uemura MT, Luk KC, Lee VM, Trojanowski JQ. Uemura N, et al. Among authors: luk kc. Trends Mol Med. 2020 Oct;26(10):936-952. doi: 10.1016/j.molmed.2020.03.012. Epub 2020 May 1. Trends Mol Med. 2020. PMID: 32371172 Free PMC article. Review.

9

Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.

Luk KC, Mills IP, Trojanowski JQ, Lee VM. Luk KC, et al. Biochemistry. 2008 Nov 25;47(47):12614-25. doi: 10.1021/bi801475r. Biochemistry. 2008. PMID: 18975920 Free PMC article.

10

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.

Luk KC, Song C, O'Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM. Luk KC, et al. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20051-6. doi: 10.1073/pnas.0908005106. Epub 2009 Nov 5. Proc Natl Acad Sci U S A. 2009. PMID: 19892735 Free PMC article.

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