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Dormancy-inducing 3D engineered matrix uncovers mechanosensitive and drug-protective FHL2-p21 signaling axis.
Bakhshandeh S, Heras U, Taïeb HM, Varadarajan AR, Lissek SM, Hücker SM, Lu X, Garske DS, Young SAE, Abaurrea A, Caffarel MM, Riestra A, Bragado P, Contzen J, Gossen M, Kirsch S, Warfsmann J, Honarnejad K, Klein CA, Cipitria A. Bakhshandeh S, et al. Among authors: klein ca. Sci Adv. 2024 Nov 8;10(45):eadr3997. doi: 10.1126/sciadv.adr3997. Epub 2024 Nov 6. Sci Adv. 2024. PMID: 39504377 Free PMC article.
Sequence error storms and the landscape of mutations in cancer.
Kirsch S, Klein CA. Kirsch S, et al. Among authors: klein ca. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14289-90. doi: 10.1073/pnas.1212246109. Epub 2012 Aug 21. Proc Natl Acad Sci U S A. 2012. PMID: 22912407 Free PMC article. No abstract available.
Ex vivo expansion of lung cancer-derived disseminated cancer cells from lymph nodes identifies cells associated with metastatic progression.
Treitschke S, Weidele K, Varadarajan AR, Feliciello G, Warfsmann J, Vorbeck S, Polzer B, Botteron C, Hoffmann M, Dechand V, Mederer T, Weber F, Werner-Klein M, Robold T, Hofmann HS, Werno C, Klein CA. Treitschke S, et al. Among authors: klein ca. Int J Cancer. 2023 Nov 15;153(10):1854-1867. doi: 10.1002/ijc.34658. Epub 2023 Aug 9. Int J Cancer. 2023. PMID: 37555668
Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients.
Stojanović Gužvić N, Lüke F, Treitschke S, Coluccio A, Hoffmann M, Feliciello G, Varadarajan AR, Lu X, Weidele K, Botteron C, Materna-Reichelt S, Keil F, Evert K, Weber F, Schamberger T, Althammer M, Grosse J, Hellwig D, Schulz C, Seitz S, Ugocsai P, Schlenska-Lange A, Mayr R, Kaiser U, Dietmaier W, Polzer B, Warfsmann J, Honarnejad K, Pukrop T, Heudobler D, Klein CA, Werno C. Stojanović Gužvić N, et al. Among authors: klein ca. Mol Oncol. 2024 Oct 5. doi: 10.1002/1878-0261.13741. Online ahead of print. Mol Oncol. 2024. PMID: 39367702 Free article.
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Werner-Klein M, Grujovic A, Irlbeck C, Obradović M, Hoffmann M, Koerkel-Qu H, Lu X, Treitschke S, Köstler C, Botteron C, Weidele K, Werno C, Polzer B, Kirsch S, Gužvić M, Warfsmann J, Honarnejad K, Czyz Z, Feliciello G, Blochberger I, Grunewald S, Schneider E, Haunschild G, Patwary N, Guetter S, Huber S, Rack B, Harbeck N, Buchholz S, Rümmele P, Heine N, Rose-John S, Klein CA. Werner-Klein M, et al. Among authors: klein ca. Nat Commun. 2020 Oct 5;11(1):4977. doi: 10.1038/s41467-020-18701-4. Nat Commun. 2020. PMID: 33020483 Free PMC article.
Therapy resistance beyond cellular dormancy.
Werner-Klein M, Klein CA. Werner-Klein M, et al. Among authors: klein ca. Nat Cell Biol. 2019 Feb;21(2):117-119. doi: 10.1038/s41556-019-0276-7. Nat Cell Biol. 2019. PMID: 30664787 No abstract available.
Targeting cancer cell dormancy.
Agudo J, Aguirre-Ghiso JA, Bhatia M, Chodosh LA, Correia AL, Klein CA. Agudo J, et al. Among authors: klein ca. Nat Rev Cancer. 2024 Feb;24(2):97-104. doi: 10.1038/s41568-023-00642-x. Epub 2023 Dec 7. Nat Rev Cancer. 2024. PMID: 38062251 Free PMC article.
215 results