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Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models.
Selvarasu K, Singh AK, Iyaswamy A, Gopalkrishnashetty Sreenivasmurthy S, Krishnamoorthi S, Bera AK, Huang JD, Durairajan SSK. Selvarasu K, et al. Among authors: durairajan ssk. Front Mol Biosci. 2022 Oct 25;9:1050768. doi: 10.3389/fmolb.2022.1050768. eCollection 2022. Front Mol Biosci. 2022. PMID: 36387285 Free PMC article.
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.
Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N, Li M. Song JX, et al. Among authors: durairajan ssk. Aging Cell. 2020 Feb;19(2):e13069. doi: 10.1111/acel.13069. Epub 2019 Dec 19. Aging Cell. 2020. PMID: 31858697 Free PMC article.
NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models.
Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Kaliyamoorthy V, Zhang H, Sreenivasmurthy SG, Malampati S, Wang ZY, Zhu Z, Tong BC, Cheung KH, Lu JH, Durairajan SSK, Li M. Iyaswamy A, et al. Among authors: durairajan ssk. J Food Drug Anal. 2020 Jan;28(1):132-146. doi: 10.1016/j.jfda.2019.09.004. Epub 2019 Oct 8. J Food Drug Anal. 2020. PMID: 31883601 Free article.
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition.
Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BC, Cheung KH, Tan JQ, Lu JH, Durairajan SSK, Song JX, Li M. Sreenivasmurthy SG, et al. Among authors: durairajan ssk. Phytomedicine. 2022 Feb;96:153887. doi: 10.1016/j.phymed.2021.153887. Epub 2021 Dec 8. Phytomedicine. 2022. PMID: 34936968
44 results