Lukacova V - Search Results

1

Physiologically-Based Pharmacokinetic Modeling of Trofinetide in Moderate Renal Impairment for Phase 1 Clinical Study Dose Selection with Model Validation.

Darwish M, Marbury TC, Nunez R, Youakim JM, An D, Darling I, Lukacova V, Bishop KM. Darwish M, et al. Among authors: lukacova v. Eur J Drug Metab Pharmacokinet. 2024 Nov 8. doi: 10.1007/s13318-024-00924-1. Online ahead of print. Eur J Drug Metab Pharmacokinet. 2024. PMID: 39516357

2

A Physiologically Based Pharmacokinetic Modeling Approach to Assess the Potential for Drug Interactions Between Trofinetide and CYP3A4-Metabolized Drugs.

Darwish M, Youakim JM, Darling I, Lukacova V, Owen JS, Bradley H. Darwish M, et al. Among authors: lukacova v. Clin Ther. 2024 Mar;46(3):194-200. doi: 10.1016/j.clinthera.2023.12.007. Epub 2024 Feb 1. Clin Ther. 2024. PMID: 38307724 Free article.

3

Effect of Hepatic Impairment on Trofinetide Exposures Using an In Silico Physiologically Based Pharmacokinetic Model.

Darwish M, Obianom ON, Youakim JM, Darling I, Lukacova V, Bradley H. Darwish M, et al. Among authors: lukacova v. Adv Ther. 2024 Aug;41(8):3328-3341. doi: 10.1007/s12325-024-02926-6. Epub 2024 Jul 4. Adv Ther. 2024. PMID: 38963587 Free PMC article.

4

Physiologically Based Pharmacokinetic Absorption Model for Pexidartinib to Evaluate the Impact of Meal Contents and Intake Timing on Drug Exposure.

Nakayama S, Lukacova V, Tanabe S, Watanabe A, Mullin J, Suarez-Sharp S, Shimizu T. Nakayama S, et al. Among authors: lukacova v. Clin Pharmacol Drug Dev. 2024 Apr;13(4):440-448. doi: 10.1002/cpdd.1385. Epub 2024 Feb 23. Clin Pharmacol Drug Dev. 2024. PMID: 38396317

5

Applying Physiologically Based Pharmacokinetic Modeling to Interpret Carbamazepine's Nonlinear Pharmacokinetics and Its Induction Potential on Cytochrome P450 3A4 and Cytochrome P450 2C9 Enzymes.

Yin X, Cicali B, Rodriguez-Vera L, Lukacova V, Cristofoletti R, Schmidt S. Yin X, et al. Among authors: lukacova v. Pharmaceutics. 2024 May 30;16(6):737. doi: 10.3390/pharmaceutics16060737. Pharmaceutics. 2024. PMID: 38931859 Free PMC article.

6

Clinical Ocular Exposure Extrapolation for a Complex Ophthalmic Suspension Using Physiologically Based Pharmacokinetic Modeling and Simulation.

Le Merdy M, Spires J, Tan ML, Zhao L, Lukacova V. Le Merdy M, et al. Among authors: lukacova v. Pharmaceutics. 2024 Jul 9;16(7):914. doi: 10.3390/pharmaceutics16070914. Pharmaceutics. 2024. PMID: 39065612 Free PMC article.

7

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses.

Le Merdy M, Szeto KX, Perrier J, Bolger MB, Lukacova V. Le Merdy M, et al. Among authors: lukacova v. Pharmaceutics. 2024 Jan 10;16(1):96. doi: 10.3390/pharmaceutics16010096. Pharmaceutics. 2024. PMID: 38258106 Free PMC article.

8

Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study.

van Osdol WW, Novakovic J, Le Merdy M, Tsakalozou E, Ghosh P, Spires J, Lukacova V. van Osdol WW, et al. Among authors: lukacova v. AAPS PharmSciTech. 2024 Feb 17;25(3):39. doi: 10.1208/s12249-024-02740-x. AAPS PharmSciTech. 2024. PMID: 38366149

9

Correction to: Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study.

van Osdol WW, Novakovic J, Le Merdy M, Tsakalozou E, Ghosh P, Spires J, Lukacova V. van Osdol WW, et al. Among authors: lukacova v. AAPS PharmSciTech. 2024 Apr 18;25(5):87. doi: 10.1208/s12249-024-02795-w. AAPS PharmSciTech. 2024. PMID: 38637409 No abstract available.

10

Development of Mechanistic In Vitro-In Vivo Extrapolation to Support Bioequivalence Assessment of Long-Acting Injectables.

Amaral Silva D, Le Merdy M, Alam KD, Wang Y, Bao Q, Malavia N, Burgess D, Lukacova V. Amaral Silva D, et al. Among authors: lukacova v. Pharmaceutics. 2024 Apr 19;16(4):552. doi: 10.3390/pharmaceutics16040552. Pharmaceutics. 2024. PMID: 38675213 Free PMC article.

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