Youakim JM - Search Results

1

Physiologically-Based Pharmacokinetic Modeling of Trofinetide in Moderate Renal Impairment for Phase 1 Clinical Study Dose Selection with Model Validation.

Darwish M, Marbury TC, Nunez R, Youakim JM, An D, Darling I, Lukacova V, Bishop KM. Darwish M, et al. Among authors: youakim jm. Eur J Drug Metab Pharmacokinet. 2024 Nov 8. doi: 10.1007/s13318-024-00924-1. Online ahead of print. Eur J Drug Metab Pharmacokinet. 2024. PMID: 39516357

2

Characterization of the Pharmacokinetics and Mass Balance of a Single Oral Dose of Trofinetide in Healthy Male Subjects.

Darwish M, Nunez R, Youakim JM, Robertson P Jr. Darwish M, et al. Among authors: youakim jm. Clin Drug Investig. 2024 Jan;44(1):21-33. doi: 10.1007/s40261-023-01322-2. Epub 2023 Nov 28. Clin Drug Investig. 2024. PMID: 38017349 Free PMC article. Clinical Trial.

3

A Physiologically Based Pharmacokinetic Modeling Approach to Assess the Potential for Drug Interactions Between Trofinetide and CYP3A4-Metabolized Drugs.

Darwish M, Youakim JM, Darling I, Lukacova V, Owen JS, Bradley H. Darwish M, et al. Among authors: youakim jm. Clin Ther. 2024 Mar;46(3):194-200. doi: 10.1016/j.clinthera.2023.12.007. Epub 2024 Feb 1. Clin Ther. 2024. PMID: 38307724 Free article.

4

Effect of Hepatic Impairment on Trofinetide Exposures Using an In Silico Physiologically Based Pharmacokinetic Model.

Darwish M, Obianom ON, Youakim JM, Darling I, Lukacova V, Bradley H. Darwish M, et al. Among authors: youakim jm. Adv Ther. 2024 Aug;41(8):3328-3341. doi: 10.1007/s12325-024-02926-6. Epub 2024 Jul 4. Adv Ther. 2024. PMID: 38963587 Free PMC article.

5

Trofinetide Treatment Demonstrates a Benefit Over Placebo for the Ability to Communicate in Rett Syndrome.

Neul JL, Percy AK, Benke TA, Berry-Kravis EM, Glaze DG, Peters SU, Marsh ED, An D, Bishop KM, Youakim JM. Neul JL, et al. Among authors: youakim jm. Pediatr Neurol. 2024 Mar;152:63-72. doi: 10.1016/j.pediatrneurol.2023.11.005. Epub 2023 Nov 23. Pediatr Neurol. 2024. PMID: 38232652 Free article. Clinical Trial.

6

Exposure-Response Efficacy Modeling to Support Trofinetide Dosing in Individuals with Rett Syndrome.

Darwish M, Passarell J, Youakim JM, Bradley H, Bishop KM. Darwish M, et al. Among authors: youakim jm. Adv Ther. 2024 Apr;41(4):1462-1480. doi: 10.1007/s12325-024-02796-y. Epub 2024 Feb 16. Adv Ther. 2024. PMID: 38363467 Free PMC article. Clinical Trial.

7

Trofinetide for the treatment of Rett syndrome: Results from the open-label extension LILAC study.

Percy AK, Neul JL, Benke TA, Berry-Kravis EM, Glaze DG, Marsh ED, An D, Bishop KM, Youakim JM. Percy AK, et al. Among authors: youakim jm. Med. 2024 Sep 13;5(9):1178-1189.e3. doi: 10.1016/j.medj.2024.05.018. Epub 2024 Jun 24. Med. 2024. PMID: 38917793 Free article. Clinical Trial.

8

Trofinetide for the treatment of Rett syndrome: Long-term safety and efficacy results of the 32-month, open-label LILAC-2 study.

Percy AK, Neul JL, Benke TA, Berry-Kravis EM, Glaze DG, Marsh ED, Barrett AM, An D, Bishop KM, Youakim JM. Percy AK, et al. Among authors: youakim jm. Med. 2024 Oct 11;5(10):1275-1281.e2. doi: 10.1016/j.medj.2024.06.007. Epub 2024 Jul 17. Med. 2024. PMID: 39025065 Free article.

9

Development of trofinetide for the treatment of Rett syndrome: from bench to bedside.

Kennedy M, Glass L, Glaze DG, Kaminsky S, Percy AK, Neul JL, Jones NE, Tropea D, Horrigan JP, Nues P, Bishop KM, Youakim JM. Kennedy M, et al. Among authors: youakim jm. Front Pharmacol. 2024 Jan 22;14:1341746. doi: 10.3389/fphar.2023.1341746. eCollection 2023. Front Pharmacol. 2024. PMID: 38318312 Free PMC article.

10

Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data.

May DM, Neul J, Piña-Garza JE, Kponee-Shovein K, Satija A, Mahendran M, Downes N, Sheng K, Lema N, Boca A, Lefebvre P, Abler V, Youakim JM, Cheng WY. May DM, et al. Among authors: youakim jm. J Comp Eff Res. 2024 Jan;13(1):e230054. doi: 10.57264/cer-2023-0054. Epub 2023 Nov 16. J Comp Eff Res. 2024. PMID: 37971297 Free PMC article.

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