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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells.
Holley CL, Monteleone M, Fisch D, Libert AES, Ju RJ, Choi JH, Condon ND, Emming S, Crawford J, Lawrence GMEP, Coombs JR, Lefevre JG, Bajracharya R, Lahoud MH, Yap AS, Hamilton N, Stehbens SJ, Kagan JC, Ariotti N, Burgener SS, Schroder K. Holley CL, et al. Among authors: emming s. Nat Immunol. 2024 Dec 4. doi: 10.1038/s41590-024-02024-3. Online ahead of print. Nat Immunol. 2024. PMID: 39633178
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.
Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K. Coombs JR, et al. Among authors: emming s. Sci Signal. 2024 Jan 23;17(820):eabg8145. doi: 10.1126/scisignal.abg8145. Epub 2024 Jan 23. Sci Signal. 2024. PMID: 38261657
Quantifying Cell Death Induced by the NLRC4 Inflammasome.
Emming S, Monteleone MM, Kambara H, Starchenko A, Alley J, Nolan MA, Li W, Kilty I, Schroder K. Emming S, et al. Methods Mol Biol. 2023;2696:199-210. doi: 10.1007/978-1-0716-3350-2_13. Methods Mol Biol. 2023. PMID: 37578724
Reversing the mitochondrial hex that bewitches NLRP3.
Mellacheruvu M, Lawrence GMEP, Emming S, Schroder K. Mellacheruvu M, et al. Among authors: emming s. Sci Immunol. 2023 Jun 23;8(84):eadh2967. doi: 10.1126/sciimmunol.adh2967. Epub 2023 Jun 16. Sci Immunol. 2023. PMID: 37327323 Review.
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release.
Labzin LI, Chew KY, Eschke K, Wang X, Esposito T, Stocks CJ, Rae J, Patrick R, Mostafavi H, Hill B, Yordanov TE, Holley CL, Emming S, Fritzlar S, Mordant FL, Steinfort DP, Subbarao K, Nefzger CM, Lagendijk AK, Gordon EJ, Parton RG, Short KR, Londrigan SL, Schroder K. Labzin LI, et al. Among authors: emming s. Sci Signal. 2023 Apr 25;16(782):eabq1366. doi: 10.1126/scisignal.abq1366. Epub 2023 Apr 25. Sci Signal. 2023. PMID: 37098119
Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R.
De Simone M, Chirichella M, Emming S, Mazzara S, Ranzani V, Gruarin P, Moschetti G, Pulvirenti N, Maglie S, Vasco C, Crosti MC, Rossetti G, Pagani M, Abrignani S, Monticelli S, Geginat J. De Simone M, et al. Among authors: emming s. Eur J Immunol. 2021 Dec;51(12):3243-3246. doi: 10.1002/eji.202149315. Epub 2021 Sep 28. Eur J Immunol. 2021. PMID: 34528258 Free PMC article.
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