Kobe B - Search Results

1

The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds.

Chen RM, Emming S, Cinnamon R, Cameron JP, Schroder K, Kobe B, Robertson AAB. Chen RM, et al. Among authors: kobe b. Org Biomol Chem. 2024 Nov 11. doi: 10.1039/d4ob01453g. Online ahead of print. Org Biomol Chem. 2024. PMID: 39526339

2

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Chitty JL, Blake KL, Blundell RD, Koh YQAE, Thompson M, Robertson AAB, Butler MS, Cooper MA, Kappler U, Williams SJ, Kobe B, Fraser JA. Chitty JL, et al. Among authors: kobe b. J Biol Chem. 2017 Jul 14;292(28):11829-11839. doi: 10.1074/jbc.M117.787994. Epub 2017 May 30. J Biol Chem. 2017. PMID: 28559277 Free PMC article.

3

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans.

Wizrah MSI, Chua SMH, Luo Z, Manik MK, Pan M, Whyte JML, Robertson AAB, Kappler U, Kobe B, Fraser JA. Wizrah MSI, et al. Among authors: kobe b. J Biol Chem. 2022 Oct;298(10):102453. doi: 10.1016/j.jbc.2022.102453. Epub 2022 Sep 5. J Biol Chem. 2022. PMID: 36063996 Free PMC article.

4

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Chitty JL, Tatzenko TL, Williams SJ, Koh YQ, Corfield EC, Butler MS, Robertson AA, Cooper MA, Kappler U, Kobe B, Fraser JA. Chitty JL, et al. Among authors: kobe b. J Biol Chem. 2017 Feb 17;292(7):3049-3059. doi: 10.1074/jbc.M116.767533. Epub 2017 Jan 6. J Biol Chem. 2017. PMID: 28062578 Free PMC article.

5

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.

Kummari LK, Butler MS, Furlong E, Blundell R, Nouwens A, Silva AB, Kappler U, Fraser JA, Kobe B, Cooper MA, Robertson AAB. Kummari LK, et al. Among authors: kobe b. Bioorg Med Chem. 2018 Nov 1;26(20):5408-5419. doi: 10.1016/j.bmc.2018.09.004. Epub 2018 Sep 5. Bioorg Med Chem. 2018. PMID: 30322754

6

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.

Rahaman MH, Thygesen SJ, Maxwell MJ, Kim H, Mudai P, Nanson JD, Jia X, Vajjhala PR, Hedger A, Vetter I, Haselhorst T, Robertson AAB, Dymock B, Ve T, Mobli M, Stacey KJ, Kobe B. Rahaman MH, et al. Among authors: kobe b. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2313055. doi: 10.1080/14756366.2024.2313055. Epub 2024 Feb 28. J Enzyme Inhib Med Chem. 2024. PMID: 38416868 Free PMC article.

7

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA. Blundell RD, et al. Among authors: kobe b. ACS Infect Dis. 2016 Sep 9;2(9):651-663. doi: 10.1021/acsinfecdis.6b00121. Epub 2016 Aug 17. ACS Infect Dis. 2016. PMID: 27759389

8

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized.

Chen KE, Richards AA, Caradoc-Davies TT, Vajjhala PR, Robin G, Lua LH, Hill JM, Schroder K, Sweet MJ, Kellie S, Kobe B, Martin J. Chen KE, et al. Among authors: kobe b. Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):774-84. doi: 10.1107/S0907444913001558. Epub 2013 Apr 11. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23633586

9

The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs.

Liu L, Lucas RM, Nanson JD, Li Y, Whitfield J, Curson JEB, Tuladhar N, Alexandrov K, Mobli M, Sweet MJ, Kobe B, Stow JL, Luo L. Liu L, et al. Among authors: kobe b. J Biol Chem. 2022 May;298(5):101857. doi: 10.1016/j.jbc.2022.101857. Epub 2022 Mar 22. J Biol Chem. 2022. PMID: 35337798 Free PMC article.

10

A non-uniform sampling approach enables studies of dilute and unstable proteins.

Miljenović T, Jia X, Lavrencic P, Kobe B, Mobli M. Miljenović T, et al. Among authors: kobe b. J Biomol NMR. 2017 Jun;68(2):119-127. doi: 10.1007/s10858-017-0091-z. Epub 2017 Feb 10. J Biomol NMR. 2017. PMID: 28188517

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