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MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy.
Harman T, Udoh M, McElroy DL, Anderson LL, Kevin RC, Banister SD, Ametovski A, Markham J, Bladen C, Doohan PT, Greba Q, Laprairie RB, Snutch TP, McGregor IS, Howland JG, Arnold JC. Harman T, et al. Among authors: doohan pt. Front Physiol. 2023 Apr 4;14:1086243. doi: 10.3389/fphys.2023.1086243. eCollection 2023. Front Physiol. 2023. PMID: 37082241 Free PMC article.
The endocannabinoid system impacts seizures in a mouse model of Dravet syndrome.
Anderson LL, Doohan PT, Hawkins NA, Bahceci D, Garai S, Thakur GA, Kearney JA, Arnold JC. Anderson LL, et al. Among authors: doohan pt. Neuropharmacology. 2022 Mar 1;205:108897. doi: 10.1016/j.neuropharm.2021.108897. Epub 2021 Nov 22. Neuropharmacology. 2022. PMID: 34822817 Free PMC article.
Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy.
Anderson LL, Heblinski M, Absalom NL, Hawkins NA, Bowen MT, Benson MJ, Zhang F, Bahceci D, Doohan PT, Chebib M, McGregor IS, Kearney JA, Arnold JC. Anderson LL, et al. Among authors: doohan pt. Br J Pharmacol. 2021 Dec;178(24):4826-4841. doi: 10.1111/bph.15661. Epub 2021 Sep 30. Br J Pharmacol. 2021. PMID: 34384142 Free PMC article.
11 results