Chen SB - Search Results

1

L-aspartate ameliorates diet-induced obesity by increasing adipocyte energy expenditure.

Guo SY, Hu YT, Rao Y, Jiang Z, Li C, Lin YW, Xu SM, Zhao DD, Wei LY, Huang SL, Li QJ, Tan JH, Chen SB, Huang ZS. Guo SY, et al. Among authors: chen sb. Diabetes Obes Metab. 2024 Nov 11. doi: 10.1111/dom.16053. Online ahead of print. Diabetes Obes Metab. 2024. PMID: 39529440

2

Discovery of a promising agent IQZ23 for the treatment of obesity and related metabolic disorders.

Rao Y, Xu Z, Hu YT, Li C, Xu YH, Song QQ, Yu H, Song BB, Chen SB, Li QJ, Huang SL, Tan JH, Ou TM, Wang HG, Zhong GP, Ye JM, Huang ZS. Rao Y, et al. Among authors: chen sb. Eur J Med Chem. 2020 Apr 15;192:112172. doi: 10.1016/j.ejmech.2020.112172. Epub 2020 Feb 27. Eur J Med Chem. 2020. PMID: 32163815

3

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis.

Rao Y, Kuang Z, Li C, Guo S, Xu Y, Zhao D, Hu Y, Song B, Jiang Z, Ge Z, Liu X, Li C, Chen S, Ye J, Huang Z, Lu Y. Rao Y, et al. Gut Microbes. 2021 Jan-Dec;13(1):1-19. doi: 10.1080/19490976.2021.1927633. Gut Microbes. 2021. PMID: 34030573 Free PMC article.

4

A novel HSF1 activator ameliorates non-alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation.

Rao Y, Li C, Hu YT, Xu YH, Song BB, Guo SY, Jiang Z, Zhao DD, Chen SB, Tan JH, Huang SL, Li QJ, Wang XJ, Zhang YJ, Ye JM, Huang ZS. Rao Y, et al. Among authors: chen sb. Br J Pharmacol. 2022 Apr;179(7):1411-1432. doi: 10.1111/bph.15727. Epub 2022 Feb 9. Br J Pharmacol. 2022. PMID: 34783017 Free article.

5

Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer.

Jiang XC, Tu FH, Wei LY, Wang BZ, Yuan H, Yuan JM, Rao Y, Huang SL, Li QJ, Ou TM, Wang HG, Tan JH, Chen SB, Huang ZS. Jiang XC, et al. Among authors: chen sb. J Med Chem. 2022 Sep 22;65(18):12346-12366. doi: 10.1021/acs.jmedchem.2c01058. Epub 2022 Sep 2. J Med Chem. 2022. PMID: 36053318

6

Fluorescent Quinolinium Derivative as Novel Mitochondria Probe and Function Modulator by Targeting Mitochondrial RNA.

Wang BZ, Zhou YC, Lin YW, Chen XC, Yu ZY, Xu YH, Tan JH, Huang ZS, Chen SB. Wang BZ, et al. Among authors: chen sb, chen xc. Molecules. 2023 Mar 16;28(6):2690. doi: 10.3390/molecules28062690. Molecules. 2023. PMID: 36985661 Free PMC article.

7

Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer.

Xu YH, Hu YT, Xu SM, Song BB, Yuan H, Zhao DD, Guo SY, Jiang Z, Wei LY, Rao Y, Tan JH, Huang SL, Li QJ, Chen SB, Huang ZS. Xu YH, et al. Among authors: chen sb. J Med Chem. 2023 Jun 8;66(11):7387-7404. doi: 10.1021/acs.jmedchem.3c00085. Epub 2023 May 30. J Med Chem. 2023. PMID: 37253101

8

Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism.

Guo SY, Wei LY, Song BB, Hu YT, Jiang Z, Zhao DD, Xu YH, Lin YW, Xu SM, Chen SB, Huang ZS. Guo SY, et al. Among authors: chen sb. Eur J Med Chem. 2023 Nov 15;260:115729. doi: 10.1016/j.ejmech.2023.115729. Epub 2023 Aug 19. Eur J Med Chem. 2023. PMID: 37607439

9

Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group.

Jiang Z, Hu YT, Guo SY, Li YX, Zhao DD, Wei LY, Lin YW, Xu SM, Huang SL, Li Q, Tan JH, Rao Y, Chen SB, Huang ZS. Jiang Z, et al. Among authors: chen sb. J Med Chem. 2024 Jul 25;67(14):12439-12458. doi: 10.1021/acs.jmedchem.4c01242. Epub 2024 Jul 12. J Med Chem. 2024. PMID: 38996004

10

Design, synthesis and structure-activity relationship of novel 2-pyrimidinylindole derivatives as orally available anti-obesity agents.

Wei LY, Lin YW, Luo JC, Li YX, Hu YT, Guo SY, Jiang Z, Zhao DD, Chen SB, Huang ZS. Wei LY, et al. Among authors: chen sb. Eur J Med Chem. 2024 Nov 5;277:116773. doi: 10.1016/j.ejmech.2024.116773. Epub 2024 Aug 16. Eur J Med Chem. 2024. PMID: 39163779

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