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Successful generation of fully human, second generation, anti-CD19 CAR T cells for clinical use in patients with diverse autoimmune disorders.
Mougiakakos D, Sengupta R, Gold R, Schroers R, Haghikia A, Lorente M, Pendleton M, Register A, Heesen C, Kröger N, Schett G, Mackensen A, Podoll A, Gutman J, Furie R, Bayer R, Distler JHW, Dietrich S, Krönke G, Bullinger L, Walker K. Mougiakakos D, et al. Among authors: mackensen a. Cytotherapy. 2024 Oct 5:S1465-3249(24)00887-9. doi: 10.1016/j.jcyt.2024.09.008. Online ahead of print. Cytotherapy. 2024. PMID: 39530971 Free article.
CAR T-cell therapy in autoimmune diseases.
Schett G, Mackensen A, Mougiakakos D. Schett G, et al. Among authors: mackensen a. Lancet. 2023 Nov 25;402(10416):2034-2044. doi: 10.1016/S0140-6736(23)01126-1. Epub 2023 Sep 22. Lancet. 2023. PMID: 37748491 Review.
Selective CAR T cell-mediated B cell depletion suppresses IFN signature in SLE.
Wilhelm A, Chambers D, Müller F, Bozec A, Grieshaber-Bouyer R, Winkler T, Mougiakakos D, Mackensen A, Schett G, Krönke G. Wilhelm A, et al. Among authors: mackensen a. JCI Insight. 2024 May 9;9(12):e179433. doi: 10.1172/jci.insight.179433. JCI Insight. 2024. PMID: 38722688 Free PMC article.
CAR T-cell perspectives in lupus - Authors' reply.
Schett G, Mackensen A, Mougiakakos D. Schett G, et al. Among authors: mackensen a. Lancet. 2024 Jul 27;404(10450):336-337. doi: 10.1016/S0140-6736(24)01266-2. Lancet. 2024. PMID: 39067897 No abstract available.
Advancements and challenges in CAR T cell therapy in autoimmune diseases.
Schett G, Müller F, Taubmann J, Mackensen A, Wang W, Furie RA, Gold R, Haghikia A, Merkel PA, Caricchio R, D'Agostino MA, Locatelli F, June CH, Mougiakakos D. Schett G, et al. Among authors: mackensen a. Nat Rev Rheumatol. 2024 Sep;20(9):531-544. doi: 10.1038/s41584-024-01139-z. Epub 2024 Aug 6. Nat Rev Rheumatol. 2024. PMID: 39107407 Review.
CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G. Müller F, et al. Among authors: mackensen a. N Engl J Med. 2024 Feb 22;390(8):687-700. doi: 10.1056/NEJMoa2308917. N Engl J Med. 2024. PMID: 38381673
CAR T-Cell Therapy in Autoimmune Disease. Reply.
Müller F, Mackensen A, Schett G. Müller F, et al. Among authors: mackensen a. N Engl J Med. 2024 May 2;390(17):1631-1632. doi: 10.1056/NEJMc2403705. N Engl J Med. 2024. PMID: 38692300 No abstract available.
Fully Human Anti-CD19 CAR T Cells Derived from Systemic Lupus Erythematosus Patients Exhibit Cytotoxicity with Reduced Inflammatory Cytokine Production.
Dingfelder J, Aigner M, Taubmann J, Minopoulou I, Park S, Kaplan CD, Cheng JK, Van Blarcom T, Schett G, Mackensen A, Lutzny-Geier G. Dingfelder J, et al. Among authors: mackensen a. Transplant Cell Ther. 2024 Jun;30(6):582.e1-582.e10. doi: 10.1016/j.jtct.2024.03.023. Epub 2024 Mar 26. Transplant Cell Ther. 2024. PMID: 38548226 Free article.
CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series.
Auth J, Müller F, Völkl S, Bayerl N, Distler JHW, Tur C, Raimondo MG, Chenguiti Fakhouri S, Atzinger A, Coppers B, Eckstein M, Liphardt AM, Bäuerle T, Tascilar K, Aigner M, Kretschmann S, Wirsching A, Taubmann J, Hagen M, Györfi AH, Kharboutli S, Krickau T, Dees C, Spörl S, Rothe T, Harrer T, Bozec A, Grieshaber-Bouyer R, Fuchs F, Kuwert T, Berking C, Horch RE, Uder M, Mackensen A, Schett G, Bergmann C. Auth J, et al. Among authors: mackensen a. Lancet Rheumatol. 2024 Nov 11:S2665-9913(24)00282-0. doi: 10.1016/S2665-9913(24)00282-0. Online ahead of print. Lancet Rheumatol. 2024. PMID: 39542003 Free article.
Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells.
Bergmann C, Müller F, Distler JHW, Györfi AH, Völkl S, Aigner M, Kretschmann S, Reimann H, Harrer T, Bayerl N, Boeltz S, Wirsching A, Taubmann J, Rösler W, Spriewald B, Wacker J, Atzinger A, Uder M, Kuwert T, Mackensen A, Schett G. Bergmann C, et al. Among authors: mackensen a. Ann Rheum Dis. 2023 Aug;82(8):1117-1120. doi: 10.1136/ard-2023-223952. Epub 2023 May 5. Ann Rheum Dis. 2023. PMID: 37147112 Free PMC article. No abstract available.
270 results