Abd El-Karim SS - Search Results

1

Therapeutic impact of a benzofuran derivative on Aluminium chloride-induced Alzheimer's disease-like neurotoxicity in rats via modulating apoptotic and Insulin 1 genes.

Rizk MZ, Ibrahim Fouad G, Aly HF, El-Rigal NS, Ahmed KA, Mohammed FF, Khalil WKB, Abd El-Karim SS. Rizk MZ, et al. Among authors: abd el karim ss. Biochem Biophys Res Commun. 2024 Dec 20;739:150971. doi: 10.1016/j.bbrc.2024.150971. Epub 2024 Nov 9. Biochem Biophys Res Commun. 2024. PMID: 39531906

2

Benzimidazole-oxindole hybrids: A novel class of selective dual CDK2 and GSK-3β inhibitors of potent anticancer activity.

Abdel-Mohsen HT, Syam YM, Abd El-Ghany MS, Abd El-Karim SS. Abdel-Mohsen HT, et al. Among authors: abd el karim ss. Arch Pharm (Weinheim). 2024 Oct;357(10):e2300721. doi: 10.1002/ardp.202300721. Epub 2024 Jul 23. Arch Pharm (Weinheim). 2024. PMID: 39041665

3

Quinazoline-oxindole hybrids as angiokinase inhibitors and anticancer agents: Design, synthesis, biological evaluation, and molecular docking studies.

Syam YM, Abd El-Karim SS, Abdel-Mohsen HT. Syam YM, et al. Among authors: abd el karim ss. Arch Pharm (Weinheim). 2024 Oct;357(10):e2300682. doi: 10.1002/ardp.202300682. Epub 2024 Jul 12. Arch Pharm (Weinheim). 2024. PMID: 38995191

4

Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021-Present).

Abdel-Mohsen HT, Anwar MM, Ahmed NS, Abd El-Karim SS, Abdelwahed SH. Abdel-Mohsen HT, et al. Among authors: abd el karim ss. Molecules. 2024 Feb 16;29(4):875. doi: 10.3390/molecules29040875. Molecules. 2024. PMID: 38398626 Free PMC article. Review.

5

Rational design and synthesis of novel quinazolinone N-acetohydrazides as type II multi-kinase inhibitors and potential anticancer agents.

Abd El-Karim SS, Syam YM, El Kerdawy AM, Abdel-Mohsen HT. Abd El-Karim SS, et al. Bioorg Chem. 2024 Jan;142:106920. doi: 10.1016/j.bioorg.2023.106920. Epub 2023 Oct 18. Bioorg Chem. 2024. PMID: 37898082

6

Development of a New Benzofuran-Pyrazole-Pyridine-Based Molecule for the Management of Osteoarthritis.

Abd El-Karim SS, Mahmoud AH, Al-Mokaddem AK, Ibrahim NE, Alkahtani HM, Zen AA, Anwar MM. Abd El-Karim SS, et al. Molecules. 2023 Sep 27;28(19):6814. doi: 10.3390/molecules28196814. Molecules. 2023. PMID: 37836657 Free PMC article.

7

Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation.

Abd El-Karim SS, Anwar MM, Ahmed NS, Syam YM, Elseginy SA, Aly HF, Younis EA, Khalil WKB, Ahmed KA, Mohammed FF, Rizk M. Abd El-Karim SS, et al. Eur J Med Chem. 2023 Nov 15;260:115766. doi: 10.1016/j.ejmech.2023.115766. Epub 2023 Aug 28. Eur J Med Chem. 2023. PMID: 37678141

8

Anti-Alzheimer activity of new coumarin-based derivatives targeting acetylcholinesterase inhibition.

Kamel NN, Aly HF, Fouad GI, Abd El-Karim SS, Anwar MM, Syam YM, Elseginy SA, Ahmed KA, Booles HF, Shalaby MB, Khalil WKB, Sandhir R, Deshwal S, Rizk MZ. Kamel NN, et al. Among authors: abd el karim ss. RSC Adv. 2023 Jun 20;13(27):18496-18510. doi: 10.1039/d3ra02344c. eCollection 2023 Jun 15. RSC Adv. 2023. PMID: 37346948 Free PMC article.

9

New Quinoxaline-Based Derivatives as PARP-1 Inhibitors: Design, Synthesis, Antiproliferative, and Computational Studies.

Syam YM, Anwar MM, Abd El-Karim SS, Elokely KM, Abdelwahed SH. Syam YM, et al. Among authors: abd el karim ss. Molecules. 2022 Aug 2;27(15):4924. doi: 10.3390/molecules27154924. Molecules. 2022. PMID: 35956876 Free PMC article.

10

New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies.

Syam YM, Anwar MM, Abd El-Karim SS, Elseginy SA, Essa BM, Sakr TM. Syam YM, et al. Among authors: abd el karim ss. RSC Adv. 2021 Nov 17;11(58):36989-37010. doi: 10.1039/d1ra06799k. eCollection 2021 Nov 10. RSC Adv. 2021. PMID: 35494381 Free PMC article.

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