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The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms.
Pham TCP, Raun SH, Havula E, Henriquez-Olguín C, Rubalcava-Gracia D, Frank E, Fritzen AM, Jannig PR, Andersen NR, Kruse R, Ali MS, Irazoki A, Halling JF, Ringholm S, Needham EJ, Hansen S, Lemminger AK, Schjerling P, Petersen MH, de Almeida ME, Jensen TE, Kiens B, Hostrup M, Larsen S, Ørtenblad N, Højlund K, Kjær M, Ruas JL, Trifunovic A, Wojtaszewski JFP, Nielsen J, Qvortrup K, Pilegaard H, Richter EA, Sylow L. Pham TCP, et al. Among authors: irazoki a. Nat Commun. 2024 Nov 13;15(1):9826. doi: 10.1038/s41467-024-54183-4. Nat Commun. 2024. PMID: 39537626 Free PMC article.
Mitochondrial fitness sustains healthy muscle aging.
Irazoki A, Zorzano A, Sebastián D. Irazoki A, et al. Aging (Albany NY). 2023 Jun 24;15(13):5956-5958. doi: 10.18632/aging.204857. Epub 2023 Jun 24. Aging (Albany NY). 2023. PMID: 37367724 Free PMC article. No abstract available.
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
Sebastián D, Sorianello E, Segalés J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Muñoz JP, Sánchez-Feutrie M, Plana N, Hernández-Álvarez MI, Serrano AL, Palacín M, Zorzano A. Sebastián D, et al. Among authors: irazoki a. EMBO J. 2016 Aug 1;35(15):1677-93. doi: 10.15252/embj.201593084. Epub 2016 Jun 22. EMBO J. 2016. PMID: 27334614 Free PMC article.