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Page 1
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms.
Pham TCP, Raun SH, Havula E, Henriquez-Olguín C, Rubalcava-Gracia D, Frank E, Fritzen AM, Jannig PR, Andersen NR, Kruse R, Ali MS, Irazoki A, Halling JF, Ringholm S, Needham EJ, Hansen S, Lemminger AK, Schjerling P, Petersen MH, de Almeida ME, Jensen TE, Kiens B, Hostrup M, Larsen S, Ørtenblad N, Højlund K, Kjær M, Ruas JL, Trifunovic A, Wojtaszewski JFP, Nielsen J, Qvortrup K, Pilegaard H, Richter EA, Sylow L. Pham TCP, et al. Among authors: needham ej. Nat Commun. 2024 Nov 13;15(1):9826. doi: 10.1038/s41467-024-54183-4. Nat Commun. 2024. PMID: 39537626 Free PMC article.
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.
Zhao JH, Stacey D, Eriksson N, Macdonald-Dunlop E, Hedman ÅK, Kalnapenkis A, Enroth S, Cozzetto D, Digby-Bell J, Marten J, Folkersen L, Herder C, Jonsson L, Bergen SE, Gieger C, Needham EJ, Surendran P; Estonian Biobank Research Team; Paul DS, Polasek O, Thorand B, Grallert H, Roden M, Võsa U, Esko T, Hayward C, Johansson Å, Gyllensten U, Powell N, Hansson O, Mattsson-Carlgren N, Joshi PK, Danesh J, Padyukov L, Klareskog L, Landén M, Wilson JF, Siegbahn A, Wallentin L, Mälarstig A, Butterworth AS, Peters JE. Zhao JH, et al. Among authors: needham ej. Nat Immunol. 2023 Nov;24(11):1960. doi: 10.1038/s41590-023-01635-6. Nat Immunol. 2023. PMID: 37679551 Free PMC article. No abstract available.
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.
Zhao JH, Stacey D, Eriksson N, Macdonald-Dunlop E, Hedman ÅK, Kalnapenkis A, Enroth S, Cozzetto D, Digby-Bell J, Marten J, Folkersen L, Herder C, Jonsson L, Bergen SE, Gieger C, Needham EJ, Surendran P; Estonian Biobank Research Team; Paul DS, Polasek O, Thorand B, Grallert H, Roden M, Võsa U, Esko T, Hayward C, Johansson Å, Gyllensten U, Powell N, Hansson O, Mattsson-Carlgren N, Joshi PK, Danesh J, Padyukov L, Klareskog L, Landén M, Wilson JF, Siegbahn A, Wallentin L, Mälarstig A, Butterworth AS, Peters JE. Zhao JH, et al. Among authors: needham ej. Nat Immunol. 2023 Sep;24(9):1540-1551. doi: 10.1038/s41590-023-01588-w. Epub 2023 Aug 10. Nat Immunol. 2023. PMID: 37563310 Free PMC article.
Targets mapped for almost all human kinase enzymes.
Humphrey SJ, Needham EJ. Humphrey SJ, et al. Among authors: needham ej. Nature. 2023 Jan;613(7945):637-638. doi: 10.1038/d41586-022-04583-7. Nature. 2023. PMID: 36631581 No abstract available.
Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action.
Needham EJ, Hingst JR, Onslev JD, Diaz-Vegas A, Leandersson MR, Huckstep H, Kristensen JM, Kido K, Richter EA, Højlund K, Parker BL, Cooke K, Yang G, Pehmøller C, Humphrey SJ, James DE, Wojtaszewski JFP. Needham EJ, et al. Cell Metab. 2024 Nov 18:S1550-4131(24)00416-9. doi: 10.1016/j.cmet.2024.10.020. Online ahead of print. Cell Metab. 2024. PMID: 39577414
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
Kristensen JM, Kjøbsted R, Larsen TJ, Carl CS, Hingst JR, Onslev J, Birk JB, Thorup A, Steenberg DE, Knudsen JR, Henriksen NS, Needham EJ, Halling JF, Gudiksen A, Rundsten CF, Hanghøj KE, Stinson SE, Hoier B, Hansen CC, Jensen TE, Hellsten Y, Pilegaard H, Grarup N, Olesen J, Humphrey SJ, James DE, Pedersen ML, Richter EA, Hansen T, Jørgensen ME, Wojtaszewski JFP. Kristensen JM, et al. Among authors: needham ej. Nat Metab. 2024 Oct 31. doi: 10.1038/s42255-024-01153-1. Online ahead of print. Nat Metab. 2024. PMID: 39482542
Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain.
Dunai C, Hetherington C, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Tharmaratnam K, Needham EJ, Williams R, Huang Y, Wood GK, Collie C, Fower A, Fox H, Ellul MA, Held M, Egbe FN, Griffiths M, Solomon T, Breen G, Kipar A, Cavanagh J, Irani SR, Vincent A, Stewart JP, Taams LS, Menon DK, Michael BD. Dunai C, et al. Among authors: needham ej. Front Immunol. 2024 Oct 14;15:1440324. doi: 10.3389/fimmu.2024.1440324. eCollection 2024. Front Immunol. 2024. PMID: 39474424 Free PMC article.
FlowAtlas: an interactive tool for high-dimensional immunophenotyping analysis bridging FlowJo with computational tools in Julia.
Coppard V, Szep G, Georgieva Z, Howlett SK, Jarvis LB, Rainbow DB, Suchanek O, Needham EJ, Mousa HS, Menon DK, Feyertag F, Mahbubani KT, Saeb-Parsy K, Jones JL. Coppard V, et al. Among authors: needham ej. Front Immunol. 2024 Jul 17;15:1425488. doi: 10.3389/fimmu.2024.1425488. eCollection 2024. Front Immunol. 2024. PMID: 39086484 Free PMC article.
Accessible interview practices for disabled scientists and engineers.
Greene SM, Schachat SR, Arita-Merino N, Cao XE, Gurnani H, Heyns M, Cagigas ML, Maikawa CL, Needham EJ, Perets EA, Phillips E, Waddle AW, Wilkinson CE, Zhou KC, Zlotnick HM. Greene SM, et al. Among authors: needham ej. iScience. 2024 Jun 26;27(7):110220. doi: 10.1016/j.isci.2024.110220. eCollection 2024 Jul 19. iScience. 2024. PMID: 39036039 Free PMC article.
40 results