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Overcoming Secondary Mutations of Type II Kinase Inhibitors.
Wang X, DeFilippis RA, Yan W, Shah NP, Li HY. Wang X, et al. Among authors: li hy. J Med Chem. 2024 Jun 27;67(12):9776-9788. doi: 10.1021/acs.jmedchem.3c01629. Epub 2024 Jun 5. J Med Chem. 2024. PMID: 38837951 Free PMC article. Review.
Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.
Zhang L, Lakkaniga NR, Bharate JB, Mcconnell N, Wang X, Kharbanda A, Leung YK, Frett B, Shah NP, Li HY. Zhang L, et al. Among authors: li hy. Eur J Med Chem. 2021 Dec 5;225:113776. doi: 10.1016/j.ejmech.2021.113776. Epub 2021 Aug 17. Eur J Med Chem. 2021. PMID: 34479037 Free PMC article.
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
Zhang L, Moccia M, Briggs DC, Bharate JB, Lakkaniga NR, Knowles P, Yan W, Tran P, Kharbanda A, Wang X, Leung YK, Frett B, Santoro M, McDonald NQ, Carlomagno F, Li HY. Zhang L, et al. Among authors: li hy. J Med Chem. 2022 Jan 27;65(2):1536-1551. doi: 10.1021/acs.jmedchem.1c01280. J Med Chem. 2022. PMID: 35081714 Free PMC article.
3,408 results