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Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors.
Ding X, Liang J, Sharko AC, Hilimire TA, Li J, Loskutov J, Mack ZT, Ji H, Schools GP, Cai C, Pugacheva EN, Chen M, Roninson IB, Broude EV. Ding X, et al. Among authors: ji h. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2414501121. doi: 10.1073/pnas.2414501121. Epub 2024 Nov 14. Proc Natl Acad Sci U S A. 2024. PMID: 39541354 Free PMC article.
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB. Chen M, et al. Among authors: ji h. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10208-10213. doi: 10.1073/pnas.1710467114. Epub 2017 Aug 30. Proc Natl Acad Sci U S A. 2017. PMID: 28855340 Free PMC article.
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo.
Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O'Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV. Ding X, et al. Among authors: ji h. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201073119. doi: 10.1073/pnas.2201073119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914167 Free PMC article.
Mediator kinase inhibition reverses castration resistance of advanced prostate cancer.
Li J, Hilimire TA, Liu Y, Wang L, Liang J, Gyorffy B, Sikirzhytski V, Ji H, Zhang L, Cheng C, Ding X, Kerr KR, Dowling CE, Chumanevich AA, Mack ZT, Schools GP, Lim CU, Ellis L, Zi X, Porter DC, Broude EV, McInnes C, Wilding G, Lilly MB, Roninson IB, Chen M. Li J, et al. Among authors: ji h. J Clin Invest. 2024 Mar 28;134(10):e176709. doi: 10.1172/JCI176709. J Clin Invest. 2024. PMID: 38546787 Free PMC article.
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB. Chen M, et al. Among authors: ji h. Nucleic Acids Res. 2023 Aug 11;51(14):7288-7313. doi: 10.1093/nar/gkad538. Nucleic Acids Res. 2023. PMID: 37378433 Free PMC article.
Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation.
Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M. Aksenova M, et al. Among authors: ji h. J Neuroimmune Pharmacol. 2020 Jun;15(2):209-223. doi: 10.1007/s11481-019-09885-8. Epub 2019 Dec 4. J Neuroimmune Pharmacol. 2020. PMID: 31802418 Free PMC article.
Suppression of HIV and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters.
Cui BC, Aksenova M, Sikirzhytskaya A, Odhiambo D, Korunova E, Sikirzhytski V, Ji H, Altomare D, Broude E, Frizzell N, Booze R, Wyatt MD, Shtutman M. Cui BC, et al. Among authors: ji h. bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.559154. doi: 10.1101/2023.09.25.559154. bioRxiv. 2023. Update in: J Neurovirol. 2024 Aug;30(4):337-352. doi: 10.1007/s13365-024-01216-9 PMID: 37808776 Free PMC article. Updated. Preprint.
6,679 results