Köhnke T - Search Results

1

DNMT3A^R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency.

Köhnke T, Karigane D, Hilgart E, Fan AC, Kayamori K, Miyauchi M, Collins CT, Suchy FP, Rangavajhula A, Feng Y, Nakauchi Y, Martinez-Montes E, Fowler JL, Loh KM, Nakauchi H, Koldobskiy MA, Feinberg AP, Majeti R. Köhnke T, et al. bioRxiv [Preprint]. 2024 Oct 29:2024.10.26.620318. doi: 10.1101/2024.10.26.620318. bioRxiv. 2024. PMID: 39553934 Free PMC article. Preprint.

2

A new era of functional experimentation in human hematopoiesis and leukemia research.

Köhnke T, Feng Y, Majeti R. Köhnke T, et al. Exp Hematol. 2024 Oct 1:104652. doi: 10.1016/j.exphem.2024.104652. Online ahead of print. Exp Hematol. 2024. PMID: 39362578 Review.

3

A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis.

Ediriwickrema A, Nakauchi Y, Fan AC, Köhnke T, Hu X, Luca BA, Kim Y, Ramakrishnan S, Nakamoto M, Karigane D, Linde MH, Azizi A, Newman AM, Gentles AJ, Majeti R. Ediriwickrema A, et al. Among authors: kohnke t. bioRxiv [Preprint]. 2024 May 10:2024.05.07.592983. doi: 10.1101/2024.05.07.592983. bioRxiv. 2024. PMID: 38766031 Free PMC article. Preprint.

4

Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119.

Köhnke T, Nuno KA, Alder CC, Gars EJ, Phan P, Fan AC, Majeti R. Köhnke T, et al. Blood Cancer Discov. 2024 May 1;5(3):202-223. doi: 10.1158/2643-3230.BCD-23-0235. Blood Cancer Discov. 2024. PMID: 38359087 Free PMC article.

5

IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation.

Landberg N, Köhnke T, Feng Y, Nakauchi Y, Fan AC, Linde MH, Karigane D, Lim K, Sinha R, Malcovati L, Thomas D, Majeti R. Landberg N, et al. Among authors: kohnke t. Blood Cancer Discov. 2024 Jan 23:OF1-OF18. doi: 10.1158/2643-3230.BCD-23-0195. Online ahead of print. Blood Cancer Discov. 2024. PMID: 38261864

6

IDH1-mutant preleukemic hematopoietic stem cells can be eliminated by inhibition of oxidative phosphorylation.

Landberg N, Köhnke T, Feng Y, Nakauchi Y, Fan AC, Linde MH, Karigane D, Lim K, Sinha R, Malcovati L, Thomas D, Majeti R. Landberg N, et al. Among authors: kohnke t. Blood Cancer Discov. 2023 Dec 13;5(2):114-31. doi: 10.1158/2643-3230.BCD-23-0195. Online ahead of print. Blood Cancer Discov. 2023. PMID: 38091010 Free PMC article.

7

Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia.

Nuno KA, Azizi A, Köhnke T, Lareau CA, Ediwirickrema A, Ryan Corces M, Satpathy AT, Majeti R. Nuno KA, et al. Among authors: kohnke t. bioRxiv [Preprint]. 2023 Oct 10:2023.10.10.561642. doi: 10.1101/2023.10.10.561642. bioRxiv. 2023. Update in: Elife. 2024 Apr 22;13:e93019. doi: 10.7554/eLife.93019. PMID: 37873452 Free PMC article. Updated. Preprint.

8

RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition.

Fan AC, Nakauchi Y, Bai L, Azizi A, Nuno KA, Zhao F, Köhnke T, Karigane D, Cruz-Hernandez D, Reinisch A, Khatri P, Majeti R. Fan AC, et al. Among authors: kohnke t. J Clin Invest. 2023 Oct 2;133(19):e167053. doi: 10.1172/JCI167053. J Clin Invest. 2023. PMID: 37581927 Free PMC article.

9

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells.

Sconocchia T, Foßelteder J, Köhnke T, Majeti R, Reinisch A. Sconocchia T, et al. Among authors: kohnke t. J Vis Exp. 2023 Mar 10;(193). doi: 10.3791/64558. J Vis Exp. 2023. PMID: 36971438

10

Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy.

Linde MH, Fan AC, Köhnke T, Trotman-Grant AC, Gurev SF, Phan P, Zhao F, Haddock NL, Nuno KA, Gars EJ, Stafford M, Marshall PL, Dove CG, Linde IL, Landberg N, Miller LP, Majzner RG, Zhang TY, Majeti R. Linde MH, et al. Among authors: kohnke t. Cancer Discov. 2023 May 4;13(5):1164-1185. doi: 10.1158/2159-8290.CD-21-0502. Cancer Discov. 2023. PMID: 36856575

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