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PKN2 is a dependency of the mesenchymal-like cancer cell state.
Killarney ST, Mesa G, Washart R, Mayro B, Dillon K, Wardell SE, Newlin M, Lu M, Abu Rmaileh A, Liu N, McDonnell DP, Pendergast AM, Wood KC. Killarney ST, et al. Among authors: washart r. Cancer Discov. 2024 Nov 19. doi: 10.1158/2159-8290.CD-24-0928. Online ahead of print. Cancer Discov. 2024. PMID: 39560431
P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.
Lin KH, Rutter JC, Xie A, Killarney ST, Vaganay C, Benaksas C, Ling F, Sodaro G, Meslin PA, Bassil CF, Fenouille N, Hoj J, Washart R, Ang HX, Cerda-Smith C, Chaintreuil P, Jacquel A, Auberger P, Forget A, Itzykson R, Lu M, Lin J, Pierobon M, Sheng Z, Li X, Chilkoti A, Owzar K, Rizzieri DA, Pardee TS, Benajiba L, Petricoin E, Puissant A, Wood KC. Lin KH, et al. Among authors: washart r. Nat Cancer. 2022 Jul;3(7):837-851. doi: 10.1038/s43018-022-00394-x. Epub 2022 Jun 6. Nat Cancer. 2022. PMID: 35668193 Free PMC article.