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The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses.
Ladak RJ, Choi JH, Luo J, Chen OJ, Mahmood N, He AJ, Naeli P, Snell PH, Bayani E, Hoang HD, Alain T, Teodoro JG, Wang J, Zhang X, Jafarnejad SM, Sonenberg N. Ladak RJ, et al. Among authors: hoang hd. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2413018121. doi: 10.1073/pnas.2413018121. Epub 2024 Nov 19. Proc Natl Acad Sci U S A. 2024. PMID: 39560640 Free PMC article.
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.
Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T. Zakaria C, et al. Among authors: hoang hd. PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30138450 Free PMC article.
Emerging translation strategies during virus-host interaction.
Hoang HD, Neault S, Pelin A, Alain T. Hoang HD, et al. Wiley Interdiscip Rev RNA. 2021 Jan;12(1):e1619. doi: 10.1002/wrna.1619. Epub 2020 Aug 5. Wiley Interdiscip Rev RNA. 2021. PMID: 32757266 Free PMC article. Review.
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD. Wang F, et al. Among authors: hoang hd. Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4. Nat Immunol. 2016. PMID: 27043414 Free PMC article.
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).
Fonseca BD, Zakaria C, Jia JJ, Graber TE, Svitkin Y, Tahmasebi S, Healy D, Hoang HD, Jensen JM, Diao IT, Lussier A, Dajadian C, Padmanabhan N, Wang W, Matta-Camacho E, Hearnden J, Smith EM, Tsukumo Y, Yanagiya A, Morita M, Petroulakis E, González JL, Hernández G, Alain T, Damgaard CK. Fonseca BD, et al. Among authors: hoang hd. J Biol Chem. 2015 Jun 26;290(26):15996-6020. doi: 10.1074/jbc.M114.621730. Epub 2015 May 4. J Biol Chem. 2015. PMID: 25940091 Free PMC article.
59 results