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Enhanced Gαq Signaling in TSC2-deficient Cells Is Required for Their Neoplastic Behavior.
Tréfier A, Tousson-Abouelazm N, Yamani L, Ibrahim S, Joung KB, Pietrobon A, Yockell-Lelievre J, Hébert TE, Ladak RJ, Takano T, Nellist M, Namkung Y, Chatenet D, Stanford WL, Laporte SA, Kristof AS. Tréfier A, et al. Among authors: ladak rj. Am J Respir Cell Mol Biol. 2024 Nov 8. doi: 10.1165/rcmb.2024-0111OC. Online ahead of print. Am J Respir Cell Mol Biol. 2024. PMID: 39514407
The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression.
Naeli P, Zhang X, Snell PH, Chatterjee S, Kamran M, Ladak RJ, Orr N, Duchaine T, Sonenberg N, Jafarnejad SM. Naeli P, et al. Among authors: ladak rj. J Cell Sci. 2023 Oct 1;136(19):jcs261286. doi: 10.1242/jcs.261286. Epub 2023 Oct 11. J Cell Sci. 2023. PMID: 37732428 Free PMC article.
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation.
Xu Z, Choi JH, Dai DL, Luo J, Ladak RJ, Li Q, Wang Y, Zhang C, Wiebe S, Liu ACH, Ran X, Yang J, Naeli P, Garzia A, Zhou L, Mahmood N, Deng Q, Elaish M, Lin R, Mahal LK, Hobman TC, Pelletier J, Alain T, Vidal SM, Duchaine T, Mazhab-Jafari MT, Mao X, Jafarnejad SM, Sonenberg N. Xu Z, et al. Among authors: ladak rj. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2204539119. doi: 10.1073/pnas.2204539119. Epub 2022 Jul 25. Proc Natl Acad Sci U S A. 2022. PMID: 35878012 Free PMC article.