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103 results

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The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo.
Brook B, Checkervarty AK, Barman S, Sweitzer C, Bosco AN, Sherman AC, Baden LR, Morrocchi E, Sanchez-Schmitz G, Palma P, Nanishi E, O'Meara TR, McGrath ME, Frieman MB, Soni D, van Haren SD, Ozonoff A, Diray-Arce J, Steen H, Dowling DJ, Levy O. Brook B, et al. Among authors: frieman mb. iScience. 2024 Sep 26;27(11):111055. doi: 10.1016/j.isci.2024.111055. eCollection 2024 Nov 15. iScience. 2024. PMID: 39569372 Free PMC article.
A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice.
Case JB, Sanapala S, Dillen C, Rhodes V, Zmasek C, Chicz TM, Switzer CE, Scheaffer SM, Georgiev G, Jacob-Dolan C, Hauser BM, Dos Anjos DCC, Adams LJ, Soudani N, Liang CY, Ying B, McNamara RP, Scheuermann RH, Boon ACM, Fremont DH, Whelan SPJ, Schmidt AG, Sette A, Grifoni A, Frieman MB, Diamond MS. Case JB, et al. Among authors: frieman mb. Cell Host Microbe. 2024 Nov 10:S1931-3128(24)00403-7. doi: 10.1016/j.chom.2024.10.016. Online ahead of print. Cell Host Microbe. 2024. PMID: 39561781
Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS-CoV-2 in mice.
Carlin AF, Beadle JR, Ardanuy J, Clark AE, Rhodes V, Garretson AF, Murphy JA, Valiaeva N, Schooley RT, Frieman MB, Hostetler KY. Carlin AF, et al. Among authors: frieman mb. Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0103924. doi: 10.1128/aac.01039-24. Epub 2024 Sep 6. Antimicrob Agents Chemother. 2024. PMID: 39240093 Free PMC article.
Global siRNA Screen Reveals Critical Human Host Factors of SARS-CoV-2 Multicycle Replication.
Yin X, Pu Y, Yuan S, Pache L, Churas C, Weston S, Riva L, Simons LM, Cisneros WJ, Clausen T, De Jesus PD, Kim HN, Fuentes D, Whitelock J, Esko J, Lord M, Mena I, García-Sastre A, Hultquist JF, Frieman MB, Ideker T, Pratt D, Martin-Sancho L, Chanda SK. Yin X, et al. Among authors: frieman mb. bioRxiv [Preprint]. 2024 Jul 10:2024.07.10.602835. doi: 10.1101/2024.07.10.602835. bioRxiv. 2024. PMID: 39026801 Free PMC article. Preprint.
SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.
McGrath ME, Xue Y, Taylor L, Dillen C, Ardanuy J, Gonzalez-Juarbe N, Baracco L, Kim R, Hart R, Assad-Garcia N, Vashee S, Frieman MB. McGrath ME, et al. Among authors: frieman mb. PLoS Pathog. 2024 May 23;20(5):e1011669. doi: 10.1371/journal.ppat.1011669. eCollection 2024 May. PLoS Pathog. 2024. PMID: 38781259 Free PMC article.
Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.
Sunshine S, Puschnik AS, Replogle JM, Laurie MT, Liu J, Zha BS, Nuñez JK, Byrum JR, McMorrow AH, Frieman MB, Winkler J, Qiu X, Rosenberg OS, Leonetti MD, Ye CJ, Weissman JS, DeRisi JL, Hein MY. Sunshine S, et al. Among authors: frieman mb. Nat Commun. 2023 Oct 6;14(1):6245. doi: 10.1038/s41467-023-41788-4. Nat Commun. 2023. PMID: 37803001 Free PMC article.
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
O'Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ. O'Meara TR, et al. Among authors: frieman mb. J Allergy Clin Immunol. 2023 Nov;152(5):1107-1120.e6. doi: 10.1016/j.jaci.2023.06.031. Epub 2023 Aug 16. J Allergy Clin Immunol. 2023. PMID: 37595760 Free PMC article.
103 results