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A pressure-jump EPR system to monitor millisecond conformational exchange rates of spin-labeled proteins.
Grosskopf JD, Sidabras JW, Altenbach C, Anderson JR, Mett RR, Strangeway RA, Hyde JS, Hubbell WL, Lerch MT. Grosskopf JD, et al. Among authors: hubbell wl. bioRxiv [Preprint]. 2024 May 11:2024.05.07.593074. doi: 10.1101/2024.05.07.593074. bioRxiv. 2024. Update in: Protein Sci. 2024 Dec;33(12):e5220. doi: 10.1002/pro.5220 PMID: 38766191 Free PMC article. Updated. Preprint.
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C. Zhao J, et al. Among authors: hubbell wl. Nature. 2024 May;629(8011):474-480. doi: 10.1038/s41586-024-07295-2. Epub 2024 Apr 10. Nature. 2024. PMID: 38600384 Free PMC article.
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies.
Parthasarathy D, Pothula KR, Dam KA, Ratnapriya S, Benet HC, Parsons R, Huang X, Sammour S, Janowska K, Harris M, Sacco S, Sodroski J, Bridges MD, Hubbell WL, Acharya P, Herschhorn A. Parthasarathy D, et al. Among authors: hubbell wl. bioRxiv [Preprint]. 2023 Dec 5:2023.09.13.557082. doi: 10.1101/2023.09.13.557082. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 26;15(1):7334. doi: 10.1038/s41467-024-51656-4 PMID: 37745449 Free PMC article. Updated. Preprint.
Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy.
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, Che T, Hubbell WL, Kobilka BK, Chen C. Zhao J, et al. Among authors: hubbell wl. bioRxiv [Preprint]. 2023 Apr 29:2023.04.28.538657. doi: 10.1101/2023.04.28.538657. bioRxiv. 2023. Update in: Nature. 2024 May;629(8011):474-480. doi: 10.1038/s41586-024-07295-2 PMID: 37163120 Free PMC article. Updated. Preprint.
Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein.
Gaffney KA, Guo R, Bridges MD, Muhammednazaar S, Chen D, Kim M, Yang Z, Schilmiller AL, Faruk NF, Peng X, Jones AD, Kim KH, Sun L, Hubbell WL, Sosnick TR, Hong H. Gaffney KA, et al. Among authors: hubbell wl. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2109169119. doi: 10.1073/pnas.2109169119. Proc Natl Acad Sci U S A. 2022. PMID: 34969836 Free PMC article.
DEER Analysis of GPCR Conformational Heterogeneity.
Elgeti M, Hubbell WL. Elgeti M, et al. Among authors: hubbell wl. Biomolecules. 2021 May 22;11(6):778. doi: 10.3390/biom11060778. Biomolecules. 2021. PMID: 34067265 Free PMC article. Review.
246 results