Lerch MT - Search Results

1

A pressure-jump EPR system to monitor millisecond conformational exchange rates of spin-labeled proteins.

Grosskopf JD, Sidabras JW, Altenbach C, Anderson JR, Mett RR, Strangeway RA, Hyde JS, Hubbell WL, Lerch MT. Grosskopf JD, et al. Among authors: lerch mt. Protein Sci. 2024 Dec;33(12):e5220. doi: 10.1002/pro.5220. Protein Sci. 2024. PMID: 39565088

2

A pressure-jump EPR system to monitor millisecond conformational exchange rates of spin-labeled proteins.

Grosskopf JD, Sidabras JW, Altenbach C, Anderson JR, Mett RR, Strangeway RA, Hyde JS, Hubbell WL, Lerch MT. Grosskopf JD, et al. Among authors: lerch mt. bioRxiv [Preprint]. 2024 May 11:2024.05.07.593074. doi: 10.1101/2024.05.07.593074. bioRxiv. 2024. Update in: Protein Sci. 2024 Dec;33(12):e5220. doi: 10.1002/pro.5220 PMID: 38766191 Free PMC article. Updated. Preprint.

3

Viewing rare conformations of the β₂ adrenergic receptor with pressure-resolved DEER spectroscopy.

Lerch MT, Matt RA, Masureel M, Elgeti M, Kumar KK, Hilger D, Foys B, Kobilka BK, Hubbell WL. Lerch MT, et al. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31824-31831. doi: 10.1073/pnas.2013904117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257561 Free PMC article.

4

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Wingler LM, et al. Among authors: lerch mt. Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10. Cell. 2019. PMID: 30639099 Free PMC article.

5

DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions.

Stadtmueller BM, Bridges MD, Dam KM, Lerch MT, Huey-Tubman KE, Hubbell WL, Bjorkman PJ. Stadtmueller BM, et al. Among authors: lerch mt. Immunity. 2018 Aug 21;49(2):235-246.e4. doi: 10.1016/j.immuni.2018.06.017. Epub 2018 Jul 31. Immunity. 2018. PMID: 30076100 Free PMC article.

6

Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1.

Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J. Bergdoll LA, et al. Among authors: lerch mt. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E172-E179. doi: 10.1073/pnas.1715464115. Epub 2017 Dec 26. Proc Natl Acad Sci U S A. 2018. PMID: 29279396 Free PMC article.

7

High-Pressure EPR and Site-Directed Spin Labeling for Mapping Molecular Flexibility in Proteins.

Lerch MT, Yang Z, Altenbach C, Hubbell WL. Lerch MT, et al. Methods Enzymol. 2015;564:29-57. doi: 10.1016/bs.mie.2015.07.004. Epub 2015 Sep 9. Methods Enzymol. 2015. PMID: 26477247

8

Saturation Recovery EPR and Nitroxide Spin Labeling for Exploring Structure and Dynamics in Proteins.

Yang Z, Bridges M, Lerch MT, Altenbach C, Hubbell WL. Yang Z, et al. Among authors: lerch mt. Methods Enzymol. 2015;564:3-27. doi: 10.1016/bs.mie.2015.07.016. Epub 2015 Aug 15. Methods Enzymol. 2015. PMID: 26477246

9

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. Dror RO, et al. Among authors: lerch mt. Science. 2015 Jun 19;348(6241):1361-5. doi: 10.1126/science.aaa5264. Science. 2015. PMID: 26089515 Free PMC article.

10

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. Manglik A, et al. Among authors: lerch mt. Cell. 2015 May 21;161(5):1101-1111. doi: 10.1016/j.cell.2015.04.043. Epub 2015 May 14. Cell. 2015. PMID: 25981665 Free PMC article.

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