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Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition.
Gotardo ÉMF, Torres LS, Zaidan BC, Gushiken LFS, Brito PL, Leonardo FC, Pellizzon CH, Millholland J, Agoulnik S, Kovarik J, Costa FF, Conran N. Gotardo ÉMF, et al. Among authors: leonardo fc. Haematologica. 2024 Nov 21. doi: 10.3324/haematol.2024.286418. Online ahead of print. Haematologica. 2024. PMID: 39568425 Free article.
Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium-dependent manner.
Nader E, Conran N, Leonardo FC, Hatem A, Boisson C, Carin R, Renoux C, Costa FF, Joly P, Brito PL, Esperti S, Bernard J, Gauthier A, Poutrel S, Bertrand Y, Garcia C, Saad STO, Egée S, Connes P. Nader E, et al. Among authors: leonardo fc. Br J Haematol. 2023 Aug;202(3):657-668. doi: 10.1111/bjh.18799. Epub 2023 Apr 3. Br J Haematol. 2023. PMID: 37011913
Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.
Brito PL, Dos Santos AF, Chweih H, Favero ME, Gotardo EMF, Silva JAF, Leonardo FC, Franco-Penteado CF, de Oliveira MG, Ferreira WA Jr, Zaidan BC, Billis A, Baldanzi G, Mashima DA, Antunes E, Saad STO, Costa FF, Conran N. Brito PL, et al. Among authors: leonardo fc. PLoS One. 2022 Feb 3;17(2):e0263424. doi: 10.1371/journal.pone.0263424. eCollection 2022. PLoS One. 2022. PMID: 35113975 Free PMC article.
Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies.
Ferreira WA Jr, Chweih H, Lanaro C, Almeida CB, Brito PL, Gotardo EMF, Torres L, Miguel LI, Franco-Penteado CF, Leonardo FC, Garcia F, Saad STO, Frenette PS, Brockschnieder D, Costa FF, Stasch JP, Sandner P, Conran N. Ferreira WA Jr, et al. Among authors: leonardo fc. J Pharmacol Exp Ther. 2020 Sep;374(3):469-478. doi: 10.1124/jpet.119.264606. Epub 2020 Jul 6. J Pharmacol Exp Ther. 2020. PMID: 32631869 Free PMC article.
Expanding the Knowledge on Lignocellulolytic and Redox Enzymes of Worker and Soldier Castes from the Lower Termite Coptotermes gestroi.
Franco Cairo JP, Carazzolle MF, Leonardo FC, Mofatto LS, Brenelli LB, Gonçalves TA, Uchima CA, Domingues RR, Alvarez TM, Tramontina R, Vidal RO, Costa FF, Costa-Leonardo AM, Paes Leme AF, Pereira GA, Squina FM. Franco Cairo JP, et al. Among authors: leonardo fc. Front Microbiol. 2016 Oct 13;7:1518. doi: 10.3389/fmicb.2016.01518. eCollection 2016. Front Microbiol. 2016. PMID: 27790186 Free PMC article.
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