Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Hirabayashi T, Kawaguchi M, Harada S, Mouri M, Takamiya R, Miki Y, Sato H, Taketomi Y, Yokoyama K, Kobayashi T, Tokuoka SM, Kita Y, Yoda E, Hara S, Mikami K, Nishito Y, Kikuchi N, Nakata R, Kaneko M, Kiyonari H, Kasahara K, Aiba T, Ikeda K, Soga T, Kurano M, Yatomi Y, Murakami M.
Hirabayashi T, et al. Among authors: takamiya r.
Cell Rep. 2023 Feb 28;42(2):111940. doi: 10.1016/j.celrep.2022.111940. Epub 2023 Jan 30.
Cell Rep. 2023.
PMID: 36719796
Free article.