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Page 1
Pancreatic CAF-derived Autotaxin (ATX) drives autocrine CTGF expression to modulate pro-tumorigenic signaling.
Volat F, Medhi R, Maggs LZ, Deken MA, Price A, Andrews L, Clark J, Taylor D, Carruthers A, Taylor-Smith E, Pacheco N, Rudge SA, Fraser A, Lopez-Clavijo AF, Sousa BC, Johnson Z, Di Conza G, van der Veen L, Shah P, Sandig H, Sharpe HJ, Farrow S. Volat F, et al. Among authors: sharpe hj. Mol Cancer Ther. 2024 Nov 21. doi: 10.1158/1535-7163.MCT-23-0522. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39570650
PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity.
Gilglioni EH, Li A, St-Pierre-Wijckmans W, Shen TK, Pérez-Chávez I, Hovhannisyan G, Lisjak M, Negueruela J, Vandenbempt V, Bauzá-Martinez J, Herranz JM, Ezeriņa D, Demine S, Feng Z, Vignane T, Otero Sanchez L, Lambertucci F, Prašnická A, Devière J, Hay DC, Encinar JA, Singh SP, Messens J, Filipovic MR, Sharpe HJ, Trépo E, Wu W, Gurzov EN. Gilglioni EH, et al. Among authors: sharpe hj. Nat Commun. 2024 Nov 4;15(1):9522. doi: 10.1038/s41467-024-53733-0. Nat Commun. 2024. PMID: 39496584 Free PMC article.
The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression.
Young KA, Wojdyla K, Lai T, Mulholland KE, Aldaz Casanova S, Antrobus R, Andrews SR, Biggins L, Mahler-Araujo B, Barton PR, Anderson KR, Fearnley GW, Sharpe HJ. Young KA, et al. Among authors: sharpe hj. J Cell Sci. 2024 Jul 15;137(14):jcs261914. doi: 10.1242/jcs.261914. Epub 2024 Jul 22. J Cell Sci. 2024. PMID: 38904097 Free PMC article.
Accelerated waning of the humoral response to COVID-19 vaccines in obesity.
van der Klaauw AA, Horner EC, Pereyra-Gerber P, Agrawal U, Foster WS, Spencer S, Vergese B, Smith M, Henning E, Ramsay ID, Smith JA, Guillaume SM, Sharpe HJ, Hay IM, Thompson S, Innocentin S, Booth LH, Robertson C, McCowan C, Kerr S, Mulroney TE, O'Reilly MJ, Gurugama TP, Gurugama LP, Rust MA, Ferreira A, Ebrahimi S, Ceron-Gutierrez L, Scotucci J, Kronsteiner B, Dunachie SJ, Klenerman P; PITCH Consortium; Park AJ, Rubino F, Lamikanra AA, Stark H, Kingston N, Estcourt L, Harvala H, Roberts DJ, Doffinger R, Linterman MA, Matheson NJ, Sheikh A, Farooqi IS, Thaventhiran JED. van der Klaauw AA, et al. Among authors: sharpe hj. Nat Med. 2023 May;29(5):1146-1154. doi: 10.1038/s41591-023-02343-2. Epub 2023 May 11. Nat Med. 2023. PMID: 37169862 Free PMC article.
ChAdOx1 nCoV-19 vaccination generates spike-specific CD8+ T cells in aged mice.
Foster WS, Newman J, Thakur N, Spencer AJ, Davies S, Woods D, Godfrey L, Ross SH, Sharpe HJ, Richard AC, Bailey D, Lambe T, Linterman MA. Foster WS, et al. Among authors: sharpe hj. Immunol Cell Biol. 2023 Jul;101(6):479-488. doi: 10.1111/imcb.12645. Epub 2023 May 6. Immunol Cell Biol. 2023. PMID: 36975169 Free PMC article.
Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination.
Foster WS, Lee JL, Thakur N, Newman J, Spencer AJ, Davies S, Woods D, Godfrey L, Hay IM, Innocentin S, Yam-Puc JC, Horner EC, Sharpe HJ, Thaventhiran JE, Bailey D, Lambe T, Linterman MA. Foster WS, et al. Among authors: sharpe hj. Cell Rep Med. 2022 Dec 20;3(12):100845. doi: 10.1016/j.xcrm.2022.100845. Epub 2022 Nov 15. Cell Rep Med. 2022. PMID: 36455555 Free PMC article.
Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma.
Yurchenko AA, Pop OT, Ighilahriz M, Padioleau I, Rajabi F, Sharpe HJ, Poulalhon N, Dreno B, Khammari A, Delord M, Alberti A, Soufir N, Battistella M, Mourah S, Bouquet F, Savina A, Besse A, Mendez-Lopez M, Grange F, Monestier S, Mortier L, Meyer N, Dutriaux C, Robert C, Saiag P, Herms F, Lambert J, de Sauvage FJ, Dumaz N, Flatz L, Basset-Seguin N, Nikolaev SI. Yurchenko AA, et al. Among authors: sharpe hj. Clin Cancer Res. 2022 Apr 1;28(7):1422-1432. doi: 10.1158/1078-0432.CCR-21-3764. Clin Cancer Res. 2022. PMID: 35078858 Free PMC article.
Protein tyrosine phosphatases in cell adhesion.
Young KA, Biggins L, Sharpe HJ. Young KA, et al. Among authors: sharpe hj. Biochem J. 2021 Mar 12;478(5):1061-1083. doi: 10.1042/BCJ20200511. Biochem J. 2021. PMID: 33710332 Free PMC article. Review.
24 results