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Page 1
AMPK regulates the maintenance and remodelling of the neuromuscular junction.
Ng SY, Mikhail AI, Mattina SR, Mohammed SA, Khan SK, Desjardins EM, Lim C, Phillips SM, Steinberg GR, Ljubicic V. Ng SY, et al. Among authors: desjardins em. Mol Metab. 2024 Nov 19;91:102066. doi: 10.1016/j.molmet.2024.102066. Online ahead of print. Mol Metab. 2024. PMID: 39571900 Free article.
Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice.
Day EA, Townsend LK, Rehal S, Batchuluun B, Wang D, Morrow MR, Lu R, Lundenberg L, Lu JH, Desjardins EM, Smith TKT, Raphenya AR, McArthur AG, Fullerton MD, Steinberg GR. Day EA, et al. Among authors: desjardins em. iScience. 2023 Oct 20;26(11):108269. doi: 10.1016/j.isci.2023.108269. eCollection 2023 Nov 17. iScience. 2023. PMID: 38026185 Free PMC article.
Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice.
Desjardins EM, Wu J, Lavoie DCT, Ahmadi E, Townsend LK, Morrow MR, Wang D, Tsakiridis EE, Batchuluun B, Fayyazi R, Kwiecien JM, Tsakiridis T, Lally JSV, Paré G, Pinkosky SL, Steinberg GR. Desjardins EM, et al. Cell Rep Med. 2023 Sep 19;4(9):101193. doi: 10.1016/j.xcrm.2023.101193. Cell Rep Med. 2023. PMID: 37729871 Free PMC article.
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR. Wang D, et al. Among authors: desjardins em. Nature. 2023 Jul;619(7968):143-150. doi: 10.1038/s41586-023-06249-4. Epub 2023 Jun 28. Nature. 2023. PMID: 37380764 Free PMC article.
The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids.
Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR. Desjardins EM, et al. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2119824119. doi: 10.1073/pnas.2119824119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409897 Free PMC article.
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia.
Morrow MR, Batchuluun B, Wu J, Ahmadi E, Leroux JM, Mohammadi-Shemirani P, Desjardins EM, Wang Z, Tsakiridis EE, Lavoie DCT, Reihani A, Smith BK, Kwiecien JM, Lally JSV, Nero TL, Parker MW, Ask K, Scott JW, Jiang L, Paré G, Pinkosky SL, Steinberg GR. Morrow MR, et al. Among authors: desjardins em. Cell Metab. 2022 Jun 7;34(6):919-936.e8. doi: 10.1016/j.cmet.2022.05.004. Cell Metab. 2022. PMID: 35675800 Free article.
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota.
Ahmed BA, Ong FJ, Barra NG, Blondin DP, Gunn E, Oreskovich SM, Szamosi JC, Syed SA, Hutchings EK, Konyer NB, Singh NP, Yabut JM, Desjardins EM, Anhê FF, Foley KP, Holloway AC, Noseworthy MD, Haman F, Carpentier AC, Surette MG, Schertzer JD, Punthakee Z, Steinberg GR, Morrison KM. Ahmed BA, et al. Among authors: desjardins em. Cell Rep Med. 2021 Sep 14;2(9):100397. doi: 10.1016/j.xcrm.2021.100397. eCollection 2021 Sep 21. Cell Rep Med. 2021. PMID: 34622234 Free PMC article.
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.
Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z. Drake JC, et al. Among authors: desjardins em. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2025932118. doi: 10.1073/pnas.2025932118. Proc Natl Acad Sci U S A. 2021. PMID: 34493662 Free PMC article.
The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue.
Wang B, Tsakiridis EE, Zhang S, Llanos A, Desjardins EM, Yabut JM, Green AE, Day EA, Smith BK, Lally JSV, Wu J, Raphenya AR, Srinivasan KA, McArthur AG, Kajimura S, Patel JS, Wade MG, Morrison KM, Holloway AC, Steinberg GR. Wang B, et al. Among authors: desjardins em. Nat Commun. 2021 Aug 27;12(1):5163. doi: 10.1038/s41467-021-25384-y. Nat Commun. 2021. PMID: 34453052 Free PMC article.
26 results