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91 results

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Page 1
Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys.
Kim H, Zenhausern R, Gentry K, Lian L, Huayamares SG, Radmand A, Loughrey D, Podilapu AR, Hatit MZC, Ni H, Li A, Shajii A, Peck HE, Han K, Hua X, Jia S, Martinez M, Lee C, Santangelo PJ, Tarantal A, Dahlman JE. Kim H, et al. Among authors: santangelo pj. Nat Biotechnol. 2024 Nov 22. doi: 10.1038/s41587-024-02470-2. Online ahead of print. Nat Biotechnol. 2024. PMID: 39578569
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA.
Chaves LCS, Orr-Burks N, Vanover D, Mosur VV, Hosking SR, Kumar E K P, Jeong H, Jung Y, Assumpção JAF, Peck HE, Nelson SL, Burke KN, Garrison MA, Arthur RA, Claussen H, Heaton NS, Lafontaine ER, Hogan RJ, Zurla C, Santangelo PJ. Chaves LCS, et al. Among authors: santangelo pj. PLoS Pathog. 2024 Jul 5;20(7):e1012345. doi: 10.1371/journal.ppat.1012345. eCollection 2024 Jul. PLoS Pathog. 2024. PMID: 38968329 Free PMC article.
mRNA-encoded Cas13 can be used to treat dengue infections in mice.
Basu M, Zurla C, Auroni TT, Vanover D, Chaves LCS, Sadhwani H, Pathak H, Basu R, Beyersdorf JP, Amuda OO, Elsharkawy A, Mosur V, Arthur RA, Claussen H, Sasser LE, Wroe JA, Peck HE, Kumar M, Brinton MA, Santangelo PJ. Basu M, et al. Among authors: santangelo pj. Nat Microbiol. 2024 Aug;9(8):2160-2172. doi: 10.1038/s41564-024-01726-6. Epub 2024 Jun 5. Nat Microbiol. 2024. PMID: 38839984
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18.
Wolfson DW, Kim NK, Lee KH, Beyersdorf JP, Langberg JJ, Fernandez N, Choi D, Zureick N, Kim TY, Bae S, Gu JM, Kirschman JL, Fan J, Sheng CY, Gottlieb Sen D, Mettler B, Sung JH, Yoon YS, Park SJ, Santangelo PJ, Cho HC. Wolfson DW, et al. Among authors: santangelo pj. Nat Biomed Eng. 2024 Sep;8(9):1124-1141. doi: 10.1038/s41551-024-01211-9. Epub 2024 May 2. Nat Biomed Eng. 2024. PMID: 38698155 Free PMC article.
Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody.
Nador E, Xia C, Santangelo PJ, Whaley KJ, Costello CE, Anderson DJ. Nador E, et al. Among authors: santangelo pj. Antibodies (Basel). 2024 Mar 6;13(1):17. doi: 10.3390/antib13010017. Antibodies (Basel). 2024. PMID: 38534207 Free PMC article.
Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.
Radmand A, Kim H, Beyersdorf J, Dobrowolski CN, Zenhausern R, Paunovska K, Huayamares SG, Hua X, Han K, Loughrey D, Hatit MZC, Del Cid A, Ni H, Shajii A, Li A, Muralidharan A, Peck HE, Tiegreen KE, Jia S, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: santangelo pj. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307801120. doi: 10.1073/pnas.2307801120. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437539 Free PMC article.
Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.
Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E. Samer S, et al. Among authors: santangelo pj. JCI Insight. 2023 Nov 22;8(22):e176882. doi: 10.1172/jci.insight.176882. JCI Insight. 2023. PMID: 37991025 Free PMC article. No abstract available.
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
Huayamares SG, Lokugamage MP, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Hong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE. Huayamares SG, et al. Among authors: santangelo pj. J Control Release. 2023 May;357:394-403. doi: 10.1016/j.jconrel.2023.04.005. Epub 2023 Apr 12. J Control Release. 2023. PMID: 37028451 Free PMC article.
91 results