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Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma.
Freitag T, Kaps P, Ramtke J, Bertels S, Zunke E, Schneider B, Becker AS, Koczan D, Dubinski D, Freiman TM, Wittig F, Hinz B, Westhoff MA, Strobel H, Meiners F, Wolter D, Engel N, Troschke-Meurer S, Bergmann-Ewert W, Staehlke S, Wolff A, Gessler F, Junghanss C, Maletzki C. Freitag T, et al. Among authors: westhoff ma. NPJ Precis Oncol. 2024 Jul 25;8(1):156. doi: 10.1038/s41698-024-00653-3. NPJ Precis Oncol. 2024. PMID: 39054369 Free PMC article.
BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts.
Westhoff M, Del Villar SG, Voelker TL, Thai PN, Spooner HC, Costa AD, Sirish P, Chiamvimonvat N, Dickson EJ, Dixon RE. Westhoff M, et al. Nat Commun. 2024 Apr 25;15(1):3528. doi: 10.1038/s41467-024-47847-8. Nat Commun. 2024. PMID: 38664444 Free PMC article.
Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes.
Roos J, Zinngrebe J, Huber-Lang M, Lupu L, Schmidt MA, Strobel H, Westhoff MA, Stifel U, Gebhard F, Wabitsch M, Mollnes TE, Debatin KM, Halbgebauer R, Fischer-Posovszky P. Roos J, et al. Among authors: westhoff ma. Cell Death Dis. 2024 Apr 23;15(4):285. doi: 10.1038/s41419-024-06676-9. Cell Death Dis. 2024. PMID: 38653969 Free PMC article.
236 results