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Analysis of beta-cell maturity and mitochondrial morphology in juvenile non-human primates exposed to maternal Western-style diet during development.
Carroll DT, Miller A, Fuhr J, Elsakr JM, Ricciardi V, Del Bene AN, Stephens S, Krystofiak E, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M. Carroll DT, et al. Front Endocrinol (Lausanne). 2024 Jul 24;15:1417437. doi: 10.3389/fendo.2024.1417437. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39114287 Free PMC article.
Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion.
Carroll DT, Elsakr JM, Miller A, Fuhr J, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M. Carroll DT, et al. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E577-E588. doi: 10.1152/ajpendo.00087.2023. Epub 2023 May 3. Am J Physiol Endocrinol Metab. 2023. PMID: 37134140 Free PMC article.
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.
Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, Breyer RM, Gannon M. Bosma KJ, et al. Among authors: carroll dt. Mol Metab. 2021 Dec;54:101347. doi: 10.1016/j.molmet.2021.101347. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626853 Free PMC article.