Wargin W - Search Results

1

Phase 1, Single-Center, Double-Blind, Randomized, Placebo-Controlled Studies of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of the Sirtuin 6 Activator SP-624 in Healthy Adults.

Rigdon G, Prescott Y, Hall J, Abernathy K, Raskin J, Wargin W. Rigdon G, et al. Among authors: wargin w. Clin Pharmacol Drug Dev. 2024 Nov 26. doi: 10.1002/cpdd.1488. Online ahead of print. Clin Pharmacol Drug Dev. 2024. PMID: 39587867

2

Pharmacokinetics and tolerability of LIQ861, a novel dry-powder formulation of treprostinil.

Roscigno R, Vaughn T, Anderson S, Wargin W, Hunt T, Hill NS. Roscigno R, et al. Among authors: wargin w. Pulm Circ. 2020 Nov 19;10(4):2045894020971509. doi: 10.1177/2045894020971509. eCollection 2020 Oct-Dec. Pulm Circ. 2020. PMID: 33282202 Free PMC article.

3

Pharmacokinetics of ADS-5102 (Amantadine) Extended Release Capsules Administered Once Daily at Bedtime for the Treatment of Dyskinesia.

Hauser RA, Pahwa R, Wargin WA, Souza-Prien CJ, McClure N, Johnson R, Nguyen JT, Patni R, Went GT. Hauser RA, et al. Among authors: wargin wa. Clin Pharmacokinet. 2019 Jan;58(1):77-88. doi: 10.1007/s40262-018-0663-4. Clin Pharmacokinet. 2019. PMID: 29777529 Free PMC article. Clinical Trial.

4

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.

He S, Roberts PJ, Sorrentino JA, Bisi JE, Storrie-White H, Tiessen RG, Makhuli KM, Wargin WA, Tadema H, van Hoogdalem EJ, Strum JC, Malik R, Sharpless NE. He S, et al. Among authors: wargin wa. Sci Transl Med. 2017 Apr 26;9(387):eaal3986. doi: 10.1126/scitranslmed.aal3986. Sci Transl Med. 2017. PMID: 28446688 Free PMC article.

5

The effect of the REG2 Anticoagulation System on thrombin generation kinetics: a pharmacodynamic and pharmacokinetic first-in-human study.

Vavalle JP, Rusconi CP, Zelenkofske S, Wargin WA, Ortel TL, Alexander JH, Povsic TJ, Becker RC. Vavalle JP, et al. Among authors: wargin wa. J Thromb Thrombolysis. 2014 Oct;38(3):275-84. doi: 10.1007/s11239-014-1081-6. J Thromb Thrombolysis. 2014. PMID: 24880800 Clinical Trial.

6

A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.

Fucharoen S, Inati A, Siritanaratku N, Thein SL, Wargin WC, Koussa S, Taher A, Chaneim N, Boosalis M, Berenson R, Perrine SP. Fucharoen S, et al. Among authors: wargin wc. Br J Haematol. 2013 May;161(4):587-93. doi: 10.1111/bjh.12304. Epub 2013 Mar 27. Br J Haematol. 2013. PMID: 23530969 Free PMC article. Clinical Trial.

7

A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease.

Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L, Labotka R, Glass J, Keefer JR, Wargin WA, Berenson R, Perrine SP. Kutlar A, et al. Among authors: wargin wa. Am J Hematol. 2012 Nov;87(11):1017-21. doi: 10.1002/ajh.23306. Epub 2012 Aug 7. Am J Hematol. 2012. PMID: 22887019 Free PMC article. Clinical Trial.

8

A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent.

Vavalle JP, Rusconi CP, Zelenkofske S, Wargin WA, Alexander JH, Becker RC. Vavalle JP, et al. Among authors: wargin wa. J Thromb Haemost. 2012 Jul;10(7):1303-11. doi: 10.1111/j.1538-7836.2012.04742.x. J Thromb Haemost. 2012. PMID: 22500821 Free article. Clinical Trial.

9

Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy.

Povsic TJ, Wargin WA, Alexander JH, Krasnow J, Krolick M, Cohen MG, Mehran R, Buller CE, Bode C, Zelenkofske SL, Rusconi CP, Becker RC; RADAR Investigators. Povsic TJ, et al. Among authors: wargin wa. Eur Heart J. 2011 Oct;32(19):2412-9. doi: 10.1093/eurheartj/ehr179. Epub 2011 Jun 30. Eur Heart J. 2011. PMID: 21724623 Clinical Trial.

10

Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.

Boosalis MS, Castaneda SA, Trudel M, Mabaera R, White GL, Lowrey CH, Emery DW, Mpollo MS, Shen L, Wargin WA, Bohacek R, Faller DV, Perrine SP. Boosalis MS, et al. Among authors: wargin wa. Blood Cells Mol Dis. 2011 Aug 15;47(2):107-16. doi: 10.1016/j.bcmd.2011.04.008. Blood Cells Mol Dis. 2011. PMID: 21641240 Free PMC article.

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