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Page 1
Rapid and efficient generation of mature retinal organoids derived from human pluripotent stem cells via optimized pharmacological modulation of Sonic hedgehog, activin A, and retinoic acid signal transduction.
Matsushita T, Onishi A, Matsuyama T, Masuda T, Ogino Y, Kageyama M, Takahashi M, Uchiumi F. Matsushita T, et al. Among authors: uchiumi f. PLoS One. 2024 Aug 9;19(8):e0308743. doi: 10.1371/journal.pone.0308743. eCollection 2024. PLoS One. 2024. PMID: 39121095 Free PMC article.
Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages.
Ogawa N, Nakajima S, Tamada K, Yokoue N, Tachibana H, Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Sato A, Kamiya T, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Ogawa N, et al. Among authors: uchiumi f. Arch Biochem Biophys. 2021 Oct 30;711:109029. doi: 10.1016/j.abb.2021.109029. Epub 2021 Sep 10. Arch Biochem Biophys. 2021. PMID: 34517011
A 3-styrylchromone converted from trimebutine 3D pharmacophore possesses dual suppressive effects on RAGE and TLR4 signaling pathways.
Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Tsukimoto M, Yoshizawa K, Takao K, Sugita Y, Kamiya T, Uchiumi F, Sakagami H, Abe T, Tanuma SI. Okazawa M, et al. Among authors: uchiumi f. Biochem Biophys Res Commun. 2021 Aug 20;566:1-8. doi: 10.1016/j.bbrc.2021.05.096. Epub 2021 Jun 7. Biochem Biophys Res Commun. 2021. PMID: 34111666
Trimebutine attenuates high mobility group box 1-receptor for advanced glycation end-products inflammatory signaling pathways.
Nakajima S, Ogawa N, Yokoue N, Tachibana H, Tamada K, Okazawa M, Sato A, Oyama T, Abe H, Kamiya T, Yoshimori A, Yoshizawa K, Inoue S, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Nakajima S, et al. Among authors: uchiumi f. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1155-1161. doi: 10.1016/j.bbrc.2020.09.126. Epub 2020 Oct 8. Biochem Biophys Res Commun. 2020. PMID: 33041002
Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors.
Tanuma SI, Katsuragi K, Oyama T, Yoshimori A, Shibasaki Y, Asawa Y, Yamazaki H, Makino K, Okazawa M, Ogino Y, Sakamoto Y, Nomura M, Sato A, Abe H, Nakamura H, Takahashi H, Tanuma N, Uchiumi F. Tanuma SI, et al. Among authors: uchiumi f. Molecules. 2020 Aug 10;25(16):3633. doi: 10.3390/molecules25163633. Molecules. 2020. PMID: 32785052 Free PMC article.
65 results