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2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.
Balzarini J, Pérez-Pérez MJ, San-Félix A, Schols D, Perno CF, Vandamme AM, Camarasa MJ, De Clercq E. Balzarini J, et al. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4392-6. doi: 10.1073/pnas.89.10.4392. Proc Natl Acad Sci U S A. 1992. PMID: 1374900 Free PMC article.
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T).
Balzarini J, Pérez-Pérez MJ, San-Félix A, Camarasa MJ, Bathurst IC, Barr PJ, De Clercq E. Balzarini J, et al. J Biol Chem. 1992 Jun 15;267(17):11831-8. J Biol Chem. 1992. PMID: 1376314 Free article.
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (TSAO) pyrimidine nucleosides.
Camarasa MJ, Pérez-Pérez MJ, San-Félix A, Balzarini J, De Clercq E. Camarasa MJ, et al. J Med Chem. 1992 Jul 24;35(15):2721-7. doi: 10.1021/jm00093a002. J Med Chem. 1992. PMID: 1495006
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1.
Balzarini J, Pérez-Pérez MJ, San-Félix A, Velazquez S, Camarasa MJ, De Clercq E. Balzarini J, et al. Antimicrob Agents Chemother. 1992 May;36(5):1073-80. doi: 10.1128/AAC.36.5.1073. Antimicrob Agents Chemother. 1992. PMID: 1510396 Free PMC article.
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives).
Balzarini J, Pérez-Pérez MJ, Vélazquez S, San-Félix A, Camarasa MJ, De Clercq E, Karlsson A. Balzarini J, et al. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5470-4. doi: 10.1073/pnas.92.12.5470. Proc Natl Acad Sci U S A. 1995. PMID: 7539917 Free PMC article.
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues.
Balzarini J, Velazquez S, San-Felix A, Karlsson A, Perez-Perez MJ, Camarasa MJ, De Clercq E. Balzarini J, et al. Mol Pharmacol. 1993 Jan;43(1):109-14. Mol Pharmacol. 1993. PMID: 7678689
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors.
Balzarini J, Karlsson A, Vandamme AM, Pérez-Pérez MJ, Zhang H, Vrang L, Oberg B, Bäckbro K, Unge T, San-Félix A, et al. Balzarini J, et al. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6952-6. doi: 10.1073/pnas.90.15.6952. Proc Natl Acad Sci U S A. 1993. PMID: 7688467 Free PMC article.
115 results