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Page 1
Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals.
Seward EM, Carlson E, Harrison T, Haworth KR, Herbert R, Kelleher FJ, Kurtz MM, Moseley J, Owen SN, Owens AP, Sadowski SJ, Swain CJ, Williams BJ. Seward EM, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2515-8. doi: 10.1016/s0960-894x(02)00506-1. Bioorg Med Chem Lett. 2002. PMID: 12182850
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
Cascieri MA, Macleod AM, Underwood D, Shiao LL, Ber E, Sadowski S, Yu H, Merchant KJ, Swain CJ, Strader CD, et al. Cascieri MA, et al. Among authors: sadowski s. J Biol Chem. 1994 Mar 4;269(9):6587-91. J Biol Chem. 1994. PMID: 7509807 Free article.
M., Merchant, K. J., Cascieri, M. A., Sadowski, S., Ber, E., Swain, C. J., and Baker, R. (1993) J. Med Chem. 14, 2044-2045). We now report the detailed characterization of the interaction of N-acetyl-L-tryptophan-3,5-bistrifluoromethyl benzyl ester (L-732,138) with …
M., Merchant, K. J., Cascieri, M. A., Sadowski, S., Ber, E., Swain, C. J., and Baker, R. (1993) J. Med Chem. 14, 2044-2045). W …
4,4-Disubstituted piperidines: a new class of NK1 antagonist.
Stevenson GI, MacLeod AM, Huscroft I, Cascieri MA, Sadowski S, Baker R. Stevenson GI, et al. Among authors: sadowski s. J Med Chem. 1995 Apr 14;38(8):1264-6. doi: 10.1021/jm00008a003. J Med Chem. 1995. PMID: 7731011 No abstract available.
N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.
Ladduwahetty T, Baker R, Cascieri MA, Chambers MS, Haworth K, Keown LE, MacIntyre DE, Metzger JM, Owen S, Rycroft W, Sadowski S, Seward EM, Shepheard SL, Swain CJ, Tattersall FD, Watt AP, Williamson DW, Hargreaves RJ. Ladduwahetty T, et al. Among authors: sadowski s. J Med Chem. 1996 Jul 19;39(15):2907-14. doi: 10.1021/jm9506534. J Med Chem. 1996. PMID: 8709125
162 results