Swain CJ - Search Results

1

Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.

MacLeod AM, Merchant KJ, Brookfield F, Kelleher F, Stevenson G, Owens AP, Swain CJ, Casiceri MA, Sadowski S, Ber E, et al. MacLeod AM, et al. Among authors: swain cj. J Med Chem. 1994 Apr 29;37(9):1269-74. doi: 10.1021/jm00035a006. J Med Chem. 1994. PMID: 7513763

2

Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals.

Seward EM, Carlson E, Harrison T, Haworth KR, Herbert R, Kelleher FJ, Kurtz MM, Moseley J, Owen SN, Owens AP, Sadowski SJ, Swain CJ, Williams BJ. Seward EM, et al. Among authors: swain cj. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2515-8. doi: 10.1016/s0960-894x(02)00506-1. Bioorg Med Chem Lett. 2002. PMID: 12182850

3

Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists.

Swain CJ, Seward EM, Cascieri MA, Fong TM, Herbert R, MacIntyre DE, Merchant KJ, Owen SN, Owens AP, Sabin V, et al. Swain CJ, et al. J Med Chem. 1995 Nov 24;38(24):4793-805. doi: 10.1021/jm00024a007. J Med Chem. 1995. PMID: 7490729

4

Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.

Cascieri MA, Macleod AM, Underwood D, Shiao LL, Ber E, Sadowski S, Yu H, Merchant KJ, Swain CJ, Strader CD, et al. Cascieri MA, et al. Among authors: swain cj. J Biol Chem. 1994 Mar 4;269(9):6587-91. J Biol Chem. 1994. PMID: 7509807 Free article.

5

N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.

MacLeod AM, Merchant KJ, Cascieri MA, Sadowski S, Ber E, Swain CJ, Baker R. MacLeod AM, et al. Among authors: swain cj. J Med Chem. 1993 Jul 9;36(14):2044-5. doi: 10.1021/jm00066a015. J Med Chem. 1993. PMID: 8393115 No abstract available.

6

N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.

Ladduwahetty T, Baker R, Cascieri MA, Chambers MS, Haworth K, Keown LE, MacIntyre DE, Metzger JM, Owen S, Rycroft W, Sadowski S, Seward EM, Shepheard SL, Swain CJ, Tattersall FD, Watt AP, Williamson DW, Hargreaves RJ. Ladduwahetty T, et al. Among authors: swain cj. J Med Chem. 1996 Jul 19;39(15):2907-14. doi: 10.1021/jm9506534. J Med Chem. 1996. PMID: 8709125

7

4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.

Stevenson GI, Huscroft I, MacLeod AM, Swain CJ, Cascieri MA, Chicchi GG, Graham MI, Harrison T, Kelleher FJ, Kurtz M, Ladduwahetty T, Merchant KJ, Metzger JM, MacIntyre DE, Sadowski S, Sohal B, Owens AP. Stevenson GI, et al. Among authors: swain cj. J Med Chem. 1998 Nov 5;41(23):4623-35. doi: 10.1021/jm980376b. J Med Chem. 1998. PMID: 9804702

8

High affinity phenylglycinol-based NK1 receptor antagonists.

Owens AP, Harrison T, Moseley JD, Swain CJ, Sadowski S, Cascieri MA. Owens AP, et al. Among authors: swain cj. Bioorg Med Chem Lett. 1998 Jan 6;8(1):51-6. doi: 10.1016/s0960-894x(97)10163-9. Bioorg Med Chem Lett. 1998. PMID: 9871627

9

An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.

Harrison T, Owens AP, Williams BJ, Swain CJ, Williams A, Carlson EJ, Rycroft W, Tattersall FD, Cascieri MA, Chicchi GG, Sadowski S, Rupniak NM, Hargreaves RJ. Harrison T, et al. Among authors: swain cj. J Med Chem. 2001 Nov 22;44(24):4296-9. doi: 10.1021/jm0109558. J Med Chem. 2001. PMID: 11708932

10

Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.

Cascieri MA, Ber E, Fong TM, Sadowski S, Bansal A, Swain C, Seward E, Frances B, Burns D, Strader CD. Cascieri MA, et al. Mol Pharmacol. 1992 Sep;42(3):458-63. Mol Pharmacol. 1992. PMID: 1383685

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