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Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma.
Schmidt-Wolf IG, Finke S, Trojaneck B, Denkena A, Lefterova P, Schwella N, Heuft HG, Prange G, Korte M, Takeya M, Dorbic T, Neubauer A, Wittig B, Huhn D. Schmidt-Wolf IG, et al. Among authors: wittig b. Br J Cancer. 1999 Nov;81(6):1009-16. doi: 10.1038/sj.bjc.6690800. Br J Cancer. 1999. PMID: 10576658 Free PMC article. Clinical Trial.
Increase in proliferation rate and normalization of TNF-alpha secretion by blockage of gene transfer-induced apoptosis in lymphocytes using low-dose cyclosporine A.
Röpke G, Ebert O, Märten A, Lefterova P, Micka B, Buttgereit P, Niemitz S, Trojaneck B, Schmidt-Wolf G, Rücker AV, Huhn D, Wittig B, Schmidt-Wolf IG. Röpke G, et al. Among authors: wittig b. Cancer Gene Ther. 2000 Nov;7(11):1411-3. doi: 10.1038/sj.cgt.7700256. Cancer Gene Ther. 2000. PMID: 11129282
Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: a first clinical phase I/II trial.
Wittig B, Märten A, Dorbic T, Weineck S, Min H, Niemitz S, Trojaneck B, Flieger D, Kruopis S, Albers A, Löffel J, Neubauer A, Albers P, Müller S, Sauerbruch T, Bieber T, Huhn D, Schmidt-Wolf IG. Wittig B, et al. Hum Gene Ther. 2001 Feb 10;12(3):267-78. doi: 10.1089/10430340150218404. Hum Gene Ther. 2001. PMID: 11177563 Clinical Trial.
TNF-alpha secretion and apoptosis of lymphocytes mediated by gene transfer.
Ebert O, Röpke G, Märten A, Lefterova P, Micka B, Buttgereit P, Niemitz S, Trojaneck B, Schmidt-Wolf G, Huhn D, Wittig B, Schmidt-Wolf IG. Ebert O, et al. Among authors: wittig b. Cytokines Cell Mol Ther. 1999 Sep;5(3):165-73. Cytokines Cell Mol Ther. 1999. PMID: 10641575
214 results