De Clercq E - Search Results

1

Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors.

Debyser Z, De Vreese K, Knops-Gerrits PP, Baekelandt V, Bhikhabhai R, Strandberg B, Pauwels R, Anné J, Desmyter J, De Clercq E. Debyser Z, et al. Among authors: de vreese k, de clercq e. Mol Pharmacol. 1993 Apr;43(4):521-6. Mol Pharmacol. 1993. PMID: 7682649

2

Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds.

Debyser Z, Pauwels R, Andries K, Desmyter J, Engelborghs Y, Janssen PA, De Clercq E. Debyser Z, et al. Among authors: de clercq e. Mol Pharmacol. 1992 Jan;41(1):203-8. Mol Pharmacol. 1992. PMID: 1370707

3

Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis.

de Vreese K, Debyser Z, Vandamme AM, Pauwels R, Desmyter J, de Clercq E, Anné J. de Vreese K, et al. Among authors: de clercq e. Virology. 1992 Jun;188(2):900-4. doi: 10.1016/0042-6822(92)90550-9. Virology. 1992. PMID: 1374986

4

Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.

Debyser Z, Pauwels R, Baba M, Desmyter J, De Clercq E. Debyser Z, et al. Among authors: de clercq e. Mol Pharmacol. 1992 May;41(5):963-8. Mol Pharmacol. 1992. PMID: 1375320

5

Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.

Debyser Z, Vandamme AM, Pauwels R, Baba M, Desmyter J, De Clercq E. Debyser Z, et al. Among authors: de clercq e. J Biol Chem. 1992 Jun 15;267(17):11769-76. J Biol Chem. 1992. PMID: 1376311 Free article.

6

Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus.

Debyser Z, De Vreese K, Pauwels R, Yamamoto N, Anné J, De Clercq E, Desmyter J. Debyser Z, et al. Among authors: de vreese k, de clercq e. J Gen Virol. 1992 Jul;73 ( Pt 7):1799-804. doi: 10.1099/0022-1317-73-7-1799. J Gen Virol. 1992. PMID: 1378481

7

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

Debyser Z, Pauwels R, Andries K, Desmyter J, Kukla M, Janssen PA, De Clercq E. Debyser Z, et al. Among authors: de clercq e. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1451-5. doi: 10.1073/pnas.88.4.1451. Proc Natl Acad Sci U S A. 1991. PMID: 1705038 Free PMC article.

8

Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.

Jonckheere H, Taymans JM, Balzarini J, Velázquez S, Camarasa MJ, Desmyter J, De Clercq E, Anné J. Jonckheere H, et al. Among authors: de clercq e. J Biol Chem. 1994 Oct 14;269(41):25255-8. J Biol Chem. 1994. PMID: 7523383 Free article.

9

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.

Pauwels R, Andries K, Debyser Z, Kukla MJ, Schols D, Breslin HJ, Woestenborghs R, Desmyter J, Janssen MA, De Clercq E, et al. Pauwels R, et al. Among authors: de clercq e. Antimicrob Agents Chemother. 1994 Dec;38(12):2863-70. doi: 10.1128/AAC.38.12.2863. Antimicrob Agents Chemother. 1994. PMID: 7535037 Free PMC article.

10

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.

Esté JA, De Vreese K, Witvrouw M, Schmit JC, Vandamme AM, Anné J, Desmyter J, Henson GW, Bridger G, De Clercq E. Esté JA, et al. Among authors: de vreese k, de clercq e. Antiviral Res. 1996 Mar;29(2-3):297-307. doi: 10.1016/0166-3542(95)00936-1. Antiviral Res. 1996. PMID: 8739608

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