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Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.
Debyser Z, Vandamme AM, Pauwels R, Baba M, Desmyter J, De Clercq E. Debyser Z, et al. Among authors: desmyter j. J Biol Chem. 1992 Jun 15;267(17):11769-76. J Biol Chem. 1992. PMID: 1376311 Free article.
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.
Jonckheere H, Taymans JM, Balzarini J, Velázquez S, Camarasa MJ, Desmyter J, De Clercq E, Anné J. Jonckheere H, et al. Among authors: desmyter j. J Biol Chem. 1994 Oct 14;269(41):25255-8. J Biol Chem. 1994. PMID: 7523383 Free article.
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.
Pauwels R, Andries K, Debyser Z, Kukla MJ, Schols D, Breslin HJ, Woestenborghs R, Desmyter J, Janssen MA, De Clercq E, et al. Pauwels R, et al. Among authors: desmyter j. Antimicrob Agents Chemother. 1994 Dec;38(12):2863-70. doi: 10.1128/AAC.38.12.2863. Antimicrob Agents Chemother. 1994. PMID: 7535037 Free PMC article.
226 results