Wadkins RM - Search Results

1

Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy.

Baker SD, Wadkins RM, Stewart CF, Beck WT, Danks MK. Baker SD, et al. Among authors: wadkins rm. Cytometry. 1995 Feb 1;19(2):134-45. doi: 10.1002/cyto.990190208. Cytometry. 1995. PMID: 7743894 Free article.

2

Characterization of topotecan-mediated redistribution of DNA topoisomerase I by digital imaging microscopy.

Wadkins RM, Danks MK, Horowitz L, Baker SD. Wadkins RM, et al. Exp Cell Res. 1998 Jun 15;241(2):332-9. doi: 10.1006/excr.1998.4033. Exp Cell Res. 1998. PMID: 9637775

3

The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase.

Morton CL, Wadkins RM, Danks MK, Potter PM. Morton CL, et al. Among authors: wadkins rm. Cancer Res. 1999 Apr 1;59(7):1458-63. Cancer Res. 1999. PMID: 10197614

4

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: wadkins rm. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546

5

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM. Hyatt JL, et al. Among authors: wadkins rm. J Med Chem. 2005 Aug 25;48(17):5543-50. doi: 10.1021/jm0504196. J Med Chem. 2005. PMID: 16107154

6

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. Hyatt JL, et al. Among authors: wadkins rm. J Med Chem. 2007 Nov 15;50(23):5727-34. doi: 10.1021/jm0706867. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941623

7

Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.

Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM. Wadkins RM, et al. Mol Pharmacol. 2001 Aug;60(2):355-62. doi: 10.1124/mol.60.2.355. Mol Pharmacol. 2001. PMID: 11455023

8

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity.

Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. Mol Pharmacol. 2004 Jun;65(6):1336-43. doi: 10.1124/mol.65.6.1336. Mol Pharmacol. 2004. PMID: 15155827

9

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. J Med Chem. 2005 Apr 21;48(8):2906-15. doi: 10.1021/jm049011j. J Med Chem. 2005. PMID: 15828829

10

Kinetics of transport of dialkyloxacarbocyanines in multidrug-resistant cell lines overexpressing P-glycoprotein: interrelationship of dye alkyl chain length, cellular flux, and drug resistance.

Wadkins RM, Houghton PJ. Wadkins RM, et al. Biochemistry. 1995 Mar 21;34(11):3858-72. doi: 10.1021/bi00011a044. Biochemistry. 1995. PMID: 7893683

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