Neidle S - Search Results

1

Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.

Jenkins TC, Hurley LH, Neidle S, Thurston DE. Jenkins TC, et al. Among authors: neidle s. J Med Chem. 1994 Dec 23;37(26):4529-37. doi: 10.1021/jm00052a012. J Med Chem. 1994. PMID: 7799403

2

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.

Thurston DE, Bose DS, Thompson AS, Howard PW, Leoni A, Croker SJ, Jenkins TC, Neidle S, Hartley JA, Hurley LH. Thurston DE, et al. Among authors: neidle s. J Org Chem. 1996 Nov 15;61(23):8141-8147. doi: 10.1021/jo951631s. J Org Chem. 1996. PMID: 11667802

3

Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition.

Nunn CM, Jenkins TC, Neidle S. Nunn CM, et al. Among authors: neidle s. Eur J Biochem. 1994 Dec 15;226(3):953-61. doi: 10.1111/j.1432-1033.1994.00953.x. Eur J Biochem. 1994. PMID: 7813486 Free article.

The structural details of the complex are discussed and compared with the closely analogous complex with pentamidine bound to the same dodecamer [Edwards, K. J., Jenkins, T. C. & Neidle, S. (1992) Biochemistry 31, 7104-7109]. The amidinium groups of the ligand d …

The structural details of the complex are discussed and compared with the closely analogous complex with pentamidine bound to the same dodec …

4

Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine.

Nunn CM, Jenkins TC, Neidle S. Nunn CM, et al. Among authors: neidle s. Biochemistry. 1993 Dec 21;32(50):13838-43. doi: 10.1021/bi00213a012. Biochemistry. 1993. PMID: 8268158

The structure provides a rationale for the superior DNA-binding properties of propamidine as compared to pentamidine [cf. Edwards, K. J., Jenkins, T. C. & Neidle, S. (1992) Biochemistry 31, 7104-7109]. This is seen to result from (i) decreased minor groove width …

The structure provides a rationale for the superior DNA-binding properties of propamidine as compared to pentamidine [cf. Edwards, K. J., Je …

5

Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation.

Skelly JV, Edwards KJ, Jenkins TC, Neidle S. Skelly JV, et al. Among authors: neidle s. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):804-8. doi: 10.1073/pnas.90.3.804. Proc Natl Acad Sci U S A. 1993. PMID: 8430089 Free PMC article.

6

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: neidle s. J Med Chem. 1998 Nov 19;41(24):4873-84. doi: 10.1021/jm981067o. J Med Chem. 1998. PMID: 9822556

7

Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties.

Edwards KJ, Jenkins TC, Neidle S. Edwards KJ, et al. Among authors: neidle s. Biochemistry. 1992 Aug 11;31(31):7104-9. doi: 10.1021/bi00146a011. Biochemistry. 1992. PMID: 1643044

8

Interaction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents.

Laughton CA, Jenkins TC, Fox KR, Neidle S. Laughton CA, et al. Among authors: neidle s. Nucleic Acids Res. 1990 Aug 11;18(15):4479-88. doi: 10.1093/nar/18.15.4479. Nucleic Acids Res. 1990. PMID: 2167469 Free PMC article.

9

Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.

Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Agbandje M, et al. Among authors: neidle s. J Med Chem. 1992 Apr 17;35(8):1418-29. doi: 10.1021/jm00086a010. J Med Chem. 1992. PMID: 1573635

10

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE. Antonow D, et al. Among authors: neidle s. J Med Chem. 2010 Apr 8;53(7):2927-41. doi: 10.1021/jm901722v. J Med Chem. 2010. PMID: 20218628

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